Results 101 to 110 of about 170,172,984 (310)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Effects of Alternative Reinforcement on Human Behavior: The Source Does Matter

, 2003
Competing theories regarding the effects of delivering periodic response-independent reinforcement (more accurately, response-independent points exchanged for money) on a baseline rate of behavior were evaluated in human subjects. Contiguity theory holds
Perone, Michael, Gregory J. Madden, Michael Perone, Madden, Gregory J.   +3 more
core   +1 more source

MODELING TAXPAYER BEHAVIOR: AN EXPERIMENTAL ANALYSIS OF RESPONSES TO TAX GAME PARAMETERS

Фінансово-кредитна діяльність: проблеми теорії та практики
The article presents the results of an experimental study of the effects of audit probability, penalty levels, and moral-ethical motivation on taxpayers’ behavior regarding the fulfillment of tax obligations.
Юрій Мискін, Володимир Краєвський, Олександр Гулянський, Сергій Лекарь, Ольга Іванишина, Оксана Мискіна   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

OBSERVING BEHAVIOR AND ATYPICALLY RESTRICTED STIMULUS CONTROL [PDF]

, 2010
Restricted stimulus control refers to discrimination learning with atypical limitations in the range of controlling stimuli or stimulus features In the study reported here 4 normally capable individuals and 10 individuals with Intellectual disabilities ...
O`DONNELL, Kristin Lombard, J. Mcilvane, FARREN, Kevin M., Universidade De São Paulo, Chata A. Dickson, WHEELER, Emily E., William J. McIlvane, Kevin M. Farren, William, Gerson Y. Tomanari, DUBE, William V., DICKSON, Chata A., Kristin Lombard O’donnell, Kristin Lombard O'Donnell, MCILVANE, William J., TOMANARI, Gerson Y., Emily E. Wheeler, William V. Dube, BALSAMO, Lyn M., O'Donnell, Kristin Lombard, Lyn M. Balsamo   +20 more
core   +1 more source

Experimental analysis of structural behavior of folded glass facades under wind pressure

Journal of Asian Architecture and Building Engineering
The glass curtain wall, widely used as a building envelope, offers remarkable adaptability to architectural design due to its diverse construction techniques.
Yang Ying, Chen Hongda, Ding Jianjun, Han Weitao, Cheng Xiqi, Ji Xiaopeng, Liu Qiang   +6 more
doaj   +1 more source

Numerical and Experimental Analysis of the Shear Behavior of Ultrahigh-Performance Concrete Construction Joints

Advances in Materials Science and Engineering, 2018
Shear performance of plain UHPC (ultrahigh-performance concrete) construction joints is studied in both experimental and analytical ways. In push-off tests, three different contact surfaces of the construction joint were considered, while the case ...
Hyun-O. Jang, Han-Seung Lee, Keunhee Cho, Jinkyu Kim   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The effects of session length on demand functions generated using FR schedules.

, 2011
In comparing open and closed economies, researchers often arrange shorter sessions under the former condition than under the latter. Several studies indicate that session length per se can affect performance and there are some data that indicate that ...
Poling, Alan, Jennifer Kinloch, Poling, A, Foster, T.M, Kinloch, J.M, Foster, TM, Kinloch, Jennifer, Alan Poling, Foster, T. Mary, T. Mary Foster   +9 more
core   +1 more source