Results 111 to 120 of about 170,172,984 (310)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Creep-fatigue behavior analysis of the 310 NBN steel: Experimental and life prediction

Journal of Materials Research and Technology
With the increasing challenge of extending the service life of structural steels components subjected to high-temperature environments, there is an urgent need to investigate the mechanisms of creep-fatigue and to develop new steels that can effectively ...
Julianna Magalhaes Garcia, Gabriel P. Potirniche, Robert Stephens, Sergio Neves Monteiro, Luiz Paulo Brandao   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Experimental study and numerical analysis on mechanical behavior of GFRP-concrete composite beam

Case Studies in Construction Materials
In order to study the mechanical properties of GFRP (glass fiber-reinforced polymers)-concrete composite beam which is a new structure with potential use in coastal areas, four pure GFRP beams and seven composite beams are designed and produced in this ...
Yonghui Huang, Chenxi Shao, Shaofeng Huang, Airong Liu   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Behavior analysis and revaluation

, 2000
Revaluation refers to phenomena in which the strength of an operant is altered by reinforcer-related manipulations that take place outside the conditioning situation in which the operant was selected.
Donahoe, J.W., Burgos, J.E.
core  

Response to sample requirements in conditional discrimination procedures [PDF]

, 2011
The present experiment examined number of training trials as a function of a required response to sample in establishing conditional discriminations and testing for responding accordance with stimulus equivalence.
Lian, Torunn, Arntzen, Erik, Eilifsen, Christoffer, Braaten, Live Fay   +3 more
core  

Joint Behavior of Full-Scale Precast Concrete Pipe Infrastructure: Experimental and Numerical Analysis

Infrastructures
This study undertakes a comprehensive experimental and numerical analysis of the structural integrity of buried RC sewerage pipes, focusing on the performance of two distinct jointing materials: cement mortar and non-shrinkage grout.
Abdul Basit, Safeer Abbas, Muhammad Mubashir Ajmal, Ubaid Ahmad Mughal, Syed Minhaj Saleem Kazmi, Muhammad Junaid Munir   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source