Results 81 to 90 of about 2,558,177 (259)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Numerical and Experimental Analysis of the Shear Behavior of Ultrahigh-Performance Concrete Construction Joints

Advances in Materials Science and Engineering, 2018
Shear performance of plain UHPC (ultrahigh-performance concrete) construction joints is studied in both experimental and analytical ways. In push-off tests, three different contact surfaces of the construction joint were considered, while the case ...
Hyun-O. Jang, Han-Seung Lee, Keunhee Cho, Jinkyu Kim   +3 more
doaj   +1 more source

Research Progress in Application of Deep Learning in Animal Behavior Analysis [PDF]

Jisuanji kexue yu tansuo
In recent years, animal behavior analysis has become one of the most important methods in the fields of neuroscience and artificial intelligence. Taking advantage of the powerful deep-learning-based image analysis technology, researchers have developed ...
SHEN Tong, WANG Shuo, LI Meng, QIN Lunming
doaj   +1 more source

Percolation, Morphogenesis, and Burgers Dynamics in Blood Vessels Formation

, 2003
Experiments of in vitro formation of blood vessels show that cells randomly spread on a gel matrix autonomously organize to form a connected vascular network. We propose a simple model which reproduces many features of the biological system. We show that
A. Coniglio, A. de Candia, A. Gamba, B. B. Mandelbrot, D. Ambrosi, D. Stauffer, E. Giraudo, F. Bussolino, G. Serini, H. E. Stanley, H. J. Jensen, L. Preziosi, M. Vergassola, P. Carmeliet, R. J. LeVeque, S. Di Talia, T. Vicsek, T. Vicsek, Ya. B. Zel’dovich   +18 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

FOX DOMESTICATION: MOLECULAR MECHANISMS INVOLVED IN SELECTION FOR BEHAVIOR

Вавиловский журнал генетики и селекции, 2014
Although animal domestication has enjoyed the attention of geneticists and evolutionary biologists since Darwin’s times, the focal question about genetic basis of this process has not been duly considered.
L. N. Trut, Yu. E. Herbeck, A. V. Kharlamova, R. G. Gulevich, A. V. Kukekova   +4 more
doaj  

Multi-scale analysis of timber framed structures filled with earth and stones [PDF]

, 2013
This paper deals with the seismic analysis of timber framed houses filled by stones and earth mortar using a multi-scale approach going from the cell to the wall and then to the house.
Daudeville, L., Grange, S., Sieffert, Y., Vieux-Champagne, F.   +3 more
core  

Thermodynamics of Random Ferromagnetic Antiferromagnetic Spin-1/2 Chains

, 1998
Using the quantum Monte Carlo Loop algorithm, we calculate the temperature dependence of the uniform susceptibility, the specific heat, the correlation length, the generalized staggered susceptibility and magnetization of a spin-1/2 chain with random ...
A. Furusaki, A. Furusaki, A.P. Wilkinson, A.P. Wilkinson, B. Ammon, B. Frischmuth, B.B. Beard, Beat Ammon, Beat Frischmuth, C. Dasgupta, C.A. Doty, D.S. Fisher, E. Dagotto, E. Lieb, E. Westerberg, E. Westerberg, H. Fukuyama, H. Fukuyama, H.G. Evertz, J.E. Hirsch, J.E. Hirsch, J.P. Renard, K. Hida, K. Yang, K.J. Runge, M. Date, M. Greven, M. Sigrist, Manfred Sigrist, Matthias Troyer, N. Nagaosa, S.-k. Ma, T.N. Nguyen, W. Marshall   +33 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source