Results 41 to 50 of about 6,178,835 (292)

Results of treatment methods in the long term of experimental septic arthritis

Acta Orthopaedica et Traumatologica Turcica, 2021
The effects of synovectomy on joint cartilage destruction were investigated by late term experimental septic arthritis in 30 New Zeland rabbits. Antibiotic treatment was begun on the sixth day after staphylococcus aureus inoculation in to the knee joint ...
Murat Gurun, Omer F. Bilgen, Oner Gedikoglu, Ufuk Aydinli   +3 more
doaj  

Effects of ulinastain on experimental arthritis.

Folia Pharmacologica Japonica, 1988
Effects of the urinary enzyme inhibitor ulinastatin on experimental arthritis were investigated. Ulinastatin at the dose of 30,000 units/kg/day, i.v., significantly restored the swelling of hind paw, inflammatory score and bone damage in adjuvant arthritic rats.
KATO, Katsuaki, OHZAWA, Nobuo, NAKAYAMA, Kazuo, NAGAO, Yuuji, MIYATA, Haruo, INABA, Hitoshi, KOSUZUME, Hiroshi, GOHDA, Kanehiro, FUKUTAKE, Katsuhiko   +8 more
openaire   +3 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

The selective inhibition of the Syk tyrosine kinase ameliorates experimental autoimmune arthritis

Frontiers in Immunology, 2023
Autoimmune arthritis – such as rheumatoid arthritis – affect a significant proportion of the population, which can cause everyday joint pain, decreased mobility and reduced quality of life.
Eszter Káposztás, Eszter Káposztás, Lili Balogh, Lili Balogh, Attila Mócsai, Attila Mócsai, Éva Kemecsei, Zoltán Jakus, Tamás Németh, Tamás Németh, Tamás Németh, Tamás Németh   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The role of eicosanoids in experimental Lyme arthritis

Frontiers in Cellular and Infection Microbiology, 2014
Experimental Lyme arthritis is an inflammatory arthritis caused by infection of mice with the spirochete, Borrelia burgdorferi. It recapitulates many of the disease parameters seen in human patients with Lyme arthritis, and thus serves as a model system ...
Charles Robert Brown, Carmela Louise Pratt   +1 more
doaj   +1 more source

Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation. [PDF]

PLoS ONE, 2013
BACKGROUND: To determine the effects of liposomal targeting of prednisolone phosphate (Lip-PLP) to synovial lining macrophages on M1 and M2 polarization in vitro and during experimental arthritis. MATERIAL AND METHODS: Experimental arthritis (antigen and
Wouter Hofkens, Rik Schelbergen, Gert Storm, Wim B van den Berg, Peter L van Lent   +4 more
doaj   +1 more source

EVALUATION OF THE THERAPEUTIC EFFECT OF THE COMBINED USE OF CRYOPRESERVED PLACENTA EXTRACT AND DICLOFENAC SODIUM IN EXPERIMENTAL RHEUMATOID ARTHRITIS BY HEMATOLOGICAL PARAMETERS

Медична наука України, 2021
Relevance. Cryopreserved placenta extract (CPE) increase the resistance of the mucous membrane of the gastrointestinal tract to the damaging effects of nonsteroidal anti-inflammatory drugs.
F. V. Hladkykh
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source