Results 21 to 30 of about 6,178,835 (292)

Regulatory T-Cells Mediate IFN-α-Induced Resistance against Antigen-Induced Arthritis

Frontiers in Immunology, 2018
ObjectiveCD4+FoxP3+CD25+ regulatory T-cells (Tregs) are important for preventing tissue destruction. Here, we investigate the role of Tregs for protection against experimental arthritis by IFN-α.MethodsArthritis was triggered by intra-articular injection
Sudeep Chenna Narendra, Jaya Prakash Chalise, Sophie Biggs, Ulrich Kalinke, Mattias Magnusson   +4 more
doaj   +1 more source

Standardized protocol and outcome measurements for the collagen antibody-induced arthritis mouse model

STAR Protocols, 2022
Summary: The murine collagen antibody-induced arthritis (CAIA) model resembles various features of human rheumatoid arthritis and is based on the intraperitoneal or intravenous injection of autoantibodies against type II collagen.
Tazio Maleitzke, Jérôme Weber, Alexander Hildebrandt, Tamara Dietrich, Sijia Zhou, Serafeim Tsitsilonis, Johannes Keller   +6 more
doaj   +1 more source

Experimental Arthritis in the Rabbit [PDF]

The American Journal of the Medical Sciences, 1916
n ...
openaire   +1 more source

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models

Frontiers in Immunology, 2018
ObjectiveRheumatoid arthritis (RA) is a chronic and progressive joint disease. It appears that anti-inflammatory feedback mechanisms that could restrain joint inflammation and restore homeostasis are insufficient to perform this control.
Claire E. J. Waterborg, Silke Beermann, Mathijs G. A. Broeren, Miranda B. Bennink, Marije I. Koenders, Peter L. E. M. van Lent, Wim B. van den Berg, Peter M. van der Kraan, Fons A. J. van de Loo   +8 more
doaj   +1 more source

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Klareskog, Lars, Lars Klareskog, Rikard Holmdahl, Kallberg, H, Padyukov, L, Lars Alfredsson, Harald Burkhardt, Padyukov, Leonid, Olsson, Lina, Holmdahl, Rikard, Lina M Olsson, Burkhardt, H, Anna-Karin Lindqvist, Leonid Padyukov, Lindqvist, Anna-Karin,, Burkhardt, Harald, Klareskog, L, Lindqvist, Anna-Karin, Olsson, Lina M., Henrik Källberg, Olsson, Lina,, Källberg, Henrik, Alfredsson, Lars, Alfredsson, L, Lund University., Holmdahl, Rikard,   +25 more
core   +1 more source

IgM-Rheumatoid factor confers primary resistance to anti-PD-1 immunotherapies in NSCLC patients by reducing CD137+T-cells

EBioMedicine, 2020
Background: ICIs have strongly improved the outcome of NSCLC patients. However, primary and secondary resistance occur during treatment in most of the patients, with several of them developing fast progressions.
Alessio Ugolini, Ilaria Grazia Zizzari, Fulvia Ceccarelli, Andrea Botticelli, Tania Colasanti, Lidia Strigari, Aurelia Rughetti, Hassan Rahimi, Fabrizio Conti, Guido Valesini, Paolo Marchetti, Marianna Nuti   +11 more
doaj   +1 more source

Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression

Arthritis Research & Therapy, 2023
Background Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are potentially useful because of their claimed high sensitivity for all RA patients, including those ...
Lorena Rodriguez-Martinez, Cristina García-Moreno, Eva Perez-Pampin, María J. Gómara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golán, José A. Gómez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmartí, Isabel Haro, Antonio González   +11 more
doaj   +1 more source

Improving the outcome of psoriatic arthritis [PDF]

, 2010
Psoriatic arthritis (PsA) is recognised to have a significant impact on functional impairment, joint damage and quality of life. The aim of this thesis was to investigate tools for early identification, to develop a clinical target for treatment and to ...
Coates, Laura Claire
core   +7 more sources

Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor beta-chain [PDF]

, 2010
Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)
Burkhardt, H, Dzhambazov, Balik, Bockermann, Robert, Bettina Sehnert, Batsalova, Tsvetelina, Harald Burkhardt, Burkhardt, Harald, Robert Bockermann, Baecklund, Johan, Batsalova, T, Bockermann, R, Dzhambazov, B, Merky, Patrick, Baecklund, J, Bäcklund, Johan, Sehnert, B, Patrick Merky, Sehnert, Bettina, Balik Dzhambazov, Tsvetelina Batsalova, Lund University., Johan Backlund, Merky, P,, Bockermann, Robert,   +23 more
core   +1 more source

Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol

Nanomaterials, 2019
Accumulated evidence suggests a pathogenic role of reactive oxygen species (ROS) in perpetually rheumatoid joints. Therefore, the application of radical scavengers for reducing the accumulation of ROS is beneficial for patients with rheumatoid arthritis (
Wen-Shuo Kuo, Chia-Tse Weng, Jian-Hua Chen, Chao-Liang Wu, Ai-Li Shiau, Jeng-Long Hsieh, Edmund Cheung So, Po-Ting Wu, Shih-Yao Chen   +8 more
doaj   +1 more source