Results 11 to 20 of about 6,178,835 (292)

Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients

Frontiers in Pharmacology, 2022
The pathway of Janus tyrosine kinases (JAKs) has a central role in the pathogenesis of Rheumatoid Arthritis (RA) by regulating multiple immune functions and cytokine production.
M. Vomero, M. Vomero, M. Caliste, C. Barbati, M. Speziali, A. I. Celia, F. Ucci, C. Ciancarella, E. Putro, T. Colasanti, G. Buoncuore, E. Corsiero, M. Bombardieri, F. R. Spinelli, F. Ceccarelli, F. Conti, C. Alessandri   +16 more
doaj   +1 more source

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses

Frontiers in Immunology, 2020
Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are two closely related tryptophan catabolizing enzymes encoded by linked genes. The IDO pathway is also immunomodulatory, with IDO1 well-characterized as a mediator of tumor immune evasion. Due to its homology
Lauren M. F. Merlo, James B. DuHadaway, James D. Montgomery, Wei-Dan Peng, Peter J. Murray, George C. Prendergast, George C. Prendergast, George C. Prendergast, Andrew J. Caton, Alexander J. Muller, Laura Mandik-Nayak   +10 more
doaj   +1 more source

Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs

Arthritis Research & Therapy, 2019
Background Autophagy has emerged as a key mechanism in the survival and function of T and B lymphocytes, and its activation was involved in apoptosis resistance in rheumatoid arthritis (RA).
M. Vomero, V. Manganelli, C. Barbati, T. Colasanti, A. Capozzi, A. Finucci, F. R. Spinelli, F. Ceccarelli, C. Perricone, S. Truglia, S. Morrone, R. Maggio, R. Misasi, M. Bombardieri, M. Di Franco, F. Conti, M. Sorice, G. Valesini, C. Alessandri   +18 more
doaj   +1 more source

Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

Frontiers in Pharmacology, 2018
Background: Gout is the most common inflammatory arthritis worldwide. It is a painful inflammatory disease induced by the deposition of monosodium urate (MSU) crystals in the joints and peri-articular tissues.
Victor Fattori, Ana C. Zarpelon, Larissa Staurengo-Ferrari, Sergio M. Borghi, Tiago H. Zaninelli, Fernando B. Da Costa, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Nilton S. Arakawa, Waldiceu A. Verri   +11 more
doaj   +1 more source

Autophagy Hijacking in PBMC From COVID-19 Patients Results in Lymphopenia

Frontiers in Immunology, 2022
Autophagy is a homeostatic process responsible for the self-digestion of intracellular components and antimicrobial defense by inducing the degradation of pathogens into autophagolysosomes. Recent findings suggest an involvement of this process in severe
Cristiana Barbati, Alessandra Ida Celia, Tania Colasanti, Marta Vomero, Mariangela Speziali, Erisa Putro, Giorgia Buoncuore, Flavia Savino, Serena Colafrancesco, Federica Maria Ucci, Claudia Ciancarella, Eugenia Balbinot, Susanna Scarpa, Francesco Natalucci, Greta Pellegrino, Fulvia Ceccarelli, Francesca Romana Spinelli, Claudio Maria Mastroianni, Fabrizio Conti, Cristiano Alessandri   +19 more
doaj   +1 more source

Autoimmune Thyroid Disease in Rheumatoid Arthritis: A Global Perspective [PDF]

, 2020
Objective. To determine the prevalence and impact of autoimmune thyroid disease (AITD) in patients with rheumatoid arthritis (RA). Methods. Eight-hundred patients were included.
Roldán, Jorge Cárdenas, Rojas-Villarraga, Adriana, Cruz-Tapias, Paola, la Hoz, Juan Castellanos-de, Giraldo-Villamil, Juliana, Montoya-Ortiz, Gladys, Mantilla, Rubén D., Anaya, Juan-Manuel, Amaya-Amaya, Jenny   +8 more
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Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

Genome Biology, 2021
Background Genome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in immune cell-specific enhancers, but the analysis so far has excluded stromal cells, such as synovial ...
Xiangyu Ge, Mojca Frank-Bertoncelj, Kerstin Klein, Amanda McGovern, Tadeja Kuret, Miranda Houtman, Blaž Burja, Raphael Micheroli, Chenfu Shi, Miriam Marks, Andrew Filer, Christopher D. Buckley, Gisela Orozco, Oliver Distler, Andrew P. Morris, Paul Martin, Stephen Eyre, Caroline Ospelt   +17 more
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Treatment recommendations for psoriatic arthritis [PDF]

, 2008
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Gladman, D.D., GRAPPA, Fiorentino, David, Taylor, William J., de Vlam, K., Helliwell, P., Kavanaugh, Arthur, FitzGerald, Oliver, Gottlieb, A. B., Helliwell, Philip, McHugh, N.J., Gladman, Dafna D., Nash, P., Mease, P.J., Boehncke, W-H., McHugh, Neil J., Soriano, E.R., Gottlieb, Alice B., Gladman, D. D., Gottlieb, A.B., FitzGerald, O., Boehncke, Wolf-Henning, Taylor, W.J., McHugh, N. J., Ritchlin, C.T., Mease, Philip J., Mease, P. J., Nash, Peter, Soriano, Enrique R., Qureshi, A. A., Taylor, W. J., Ritchlin, Christopher T., Ritchlin, C. T., Kavanaugh, A., Qureshi, Abrar A., Qureshi, A.A., Boehncke, W. H., Fiorentino, D., Vlam, Kurt de, Soriano, E. R.   +39 more
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Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica

Nature Communications, 2020
Type I IFN has apposing effects in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Here the authors perform molecular profiling of NMOSD patients and mouse mechanistic experiments of neuro-inflammation to show that IFN-I ...
Agnieshka M. Agasing, Qi Wu, Bhuwan Khatri, Nadja Borisow, Klemens Ruprecht, Alexander Ulrich Brandt, Saurabh Gawde, Gaurav Kumar, James L. Quinn, Rose M. Ko, Yang Mao-Draayer, Christopher J. Lessard, Friedemann Paul, Robert C. Axtell   +13 more
doaj   +1 more source

Arthritis and disability [PDF]

, 2014
Executive summary: Arthritis Australia commissioned the Social Policy Research Centre (SPRC) at UNSW Australia to carry out research on the lived experience of people with arthritis related conditions.
Shona Bates, Karen Fisher, Fisher, KR ; https://orcid.org/, Bates, S ; https://orcid.org/, Smedley, C, Wong, M ; https://orcid.org/, Melissa Wong, Rosemary Kayess, Charlotte Smedley, Kayess, R   +9 more
core   +2 more sources