Results 31 to 40 of about 6,178,835 (292)

ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES

Медицинская иммунология, 2016
Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit,
M. S. Drutskaya, E. A. Gorshkova, A. S. Zhdanova, K.-S. Atretkhany, V. S. Gogoleva, R. V. Zvartsev, A. A. Kruglov, S. A. Nedospasov   +7 more
doaj   +1 more source

Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model

Arthritis Research & Therapy, 2020
Background Porphyromonas gingivalis (Pg) infection causes periodontal disease and exacerbates rheumatoid arthritis (RA). It is reported that inoculation of periodontopathogenic bacteria (i.e., Pg) can alter gut microbiota composition in the animal models.
Yuta Hamamoto, Kazuhisa Ouhara, Syuichi Munenaga, Mikio Shoji, Tatsuhiko Ozawa, Jyunzo Hisatsune, Isamu Kado, Mikihito Kajiya, Shinji Matsuda, Toshihisa Kawai, Noriyoshi Mizuno, Tsuyoshi Fujita, Shintaro Hirata, Kotaro Tanimoto, Koji Nakayama, Hiroyuki Kishi, Eiji Sugiyama, Hidemi Kurihara   +17 more
doaj   +1 more source

Circadian Disorganization in Experimental Arthritis

Neurosignals, 2003
This review discusses the experimental evidence indicating that arthritis disrupts circadian organization, which was mainly derived from animal studies employing Freund's complete mycobacterial adjuvant (FCA). The defense response to antigenic challenge, mediated in part by cytokines, includes changes in chronobiological central nervous system function,
Daniel P, Cardinali, Ana I, Esquifino
openaire   +2 more sources

24-hour activity and sleep profiles in arthritis

, 2020
Objectives: Identify 24-hour activity-sleep profiles in adults with arthritis and explore factors associated with profile membership. Methods: Cross-sectional cohort, using baseline data from two randomized trials studying activity counselling for ...
Feehan, Lynne M., Lynne M. Feehan, Na Lu, Lu, Na, Xie, Hue, Li, Linda C., Linda C. Li, Hui Xie   +7 more
core   +1 more source

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study. [PDF]

, 2015
INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate ...
Kelly, S, Maria DiCicco, Hands, RE, Frances Humby, Riahi, S, Nora Ng, Michele Bombardieri, Arti Mahto, Sudeh Riahi, Humby, F, DiCicco, M, Rebecca E Hands, Marrelli, A, Pitzalis, C, Stephen Kelly, Pyne, D, Lu Zou, Bombardieri, M, Mahto, A, Ng, N, Costantino Pitzalis, Zou, L, Debasish Pyne, Alessandra Marrelli   +23 more
core   +1 more source

Dendritic cells transfected with DNA constructs encoding CCR9, IL-10, and type II collagen demonstrate induction of immunological tolerance in an arthritis model

Frontiers in Immunology
IntroductionRestoring immune tolerance is a promising area of therapy for autoimmune diseases. One method that helps restore immunological tolerance is the approach using tolerogenic dendritic cells (tolDCs).
Marina S. Fisher, Vasily V. Kurilin, Aleksey S. Bulygin, Julia A. Shevchenko, Julia G. Philippova, Oleg S. Taranov, Elena K. Ivleva, Amir Z. Maksyutov, Amir Z. Maksyutov, Sergey V. Sennikov   +9 more
doaj   +1 more source

Does testosterone influence the association between sleep and frailty in men: results from the European Male Aging Study

BMC Geriatrics, 2023
Background Previous studies have suggested an association between sleep disturbance and frailty. The mechanism is unknown, although it has been suggested that hormonal factors may play a role.
Seema D. Sharma, Michael J. Cook, Leen Antonio, Evelien Gielen, Gyorgy Bartfai, Felipe F. Casanueva, Ilpo T. Huhtaniemi, Mario Maggi, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick C. Wu, Terence W. O’Neill   +14 more
doaj   +1 more source

Education mediating the associations between early life factors and frailty: a cross-sectional study of the UK Biobank

BMJ Open, 2023
Objectives Exposures in utero and during infancy may impact the development of diseases later in life. They may be linked with development of frailty, although the mechanism is unclear.
Terence W O'Neill, Neil Pendleton, Antony Payton, Asri Maharani, Altug Didikoglu, Maria Mercè Canal   +5 more
doaj   +1 more source

Effectiveness of Academic Detailing to Optimize Medication Prescribing Behaviour of Family Physicians

Journal of Pharmacy & Pharmaceutical Sciences, 2013
PURPOSE. To synthesize current knowledge about the effectiveness and the magnitude of the effect, of Academic Detailing (AD), as a stand-alone intervention, at modifying drug prescription behavior of Family Physicians (FPs) in primary care settings ...
Harpreet K Chhina, Vidula M Bhole, Charles Goldsmith, Wendy Hall, Janusz Kaczorowski, Diane Lacaille   +5 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source