Results 121 to 130 of about 49,920 (245)

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Extracellular Vesicle‐Associated IL4 Displays Enhanced Anti‐Inflammatory Properties in Microglial Cells

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Neuroinflammation and neurodegeneration are strictly related phenomena, characterized by dysregulation of microglia, central nervous system (CNS) resident immune cells. Interleukin‐4 (IL4) has shown beneficial abilities to re‐establish microglial homeostasis in experimental models of CNS traumatic injury, stroke and multiple sclerosis, but its
Giulia Marostica, Chiara Frigè, Annamaria Finardi, Alessandra Mandelli, Susanna Manenti, Stella Siciliani, Paola Podini, Ivan De Curtis, Luca Muzio, Elena Rossi, Paola de Candia, Roberto Furlan   +11 more
wiley   +1 more source

Peptide-functionalized polymeric nanoparticles for active targeting of damaged tissue in animals with experimental autoimmune encephalomyelitis

, 2015
Increased permeability of blood vessels is an indicator for various injuries and diseases, including multiple sclerosis (MS), of the central nervous system.
Pearce, Damien D., Otero, Anthony, Ghosh, Mousumi, Dargaville, Tim R, Dalton, Paul D., Pearse, Damien D, Dargaville, Tim R., Goss, Ben, Fuhrmann, Tobias, Dalton, Paul D   +9 more
core   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice

, 2011
The adhesion molecule P-selectin glycoprotein ligand (PSGL)-1 has been suggested to be involved in the immunopathogenesis of multiple sclerosis (MS). However, in C57BL/6 mice PSGL-1 was found to be dispensible for the development of MOG(aa35-55)-induced ...
Ruben Bill, Axinia Döring, Bill, Ruben, Engelhardt, Britta, Urban Deutsch, Deutsch, Urban, Britta Engelhardt, Döring, Axinia   +7 more
core   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Development of a novel model of optic neuritis to assess neuroprotective and repair strategies in multiple sclerosis

, 2012
PhDMultiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS), which often affects the optic nerve pathway. Optic neuritis (ON) is a clinical feature of MS that can cause loss of vision due to conduction block and ...
Lidster, Katie
core  

Preventive effect of injections of vitamin D on the levels of Klotho in the brain tissue of female lewis rats with experimental autoimmune ensephalomyelitis

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introdution: The aim of this study was to investigate the effect of vitamin D supplementation on Klotho levels of the brain tissue. Methods: In this laboratory experimental study, 25 female Lewis rats, after 2 weeks adaptation to lab environmental, were ...
seyedeh fatemeh fatemi, zia fallah mohammadi, vahid Talebi, Sayed mojtaba Hosseini   +3 more
doaj  

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Baicalin reduces the severity of experimental autoimmune encephalomyelitis

Brazilian Journal of Medical and Biological Research, 2007
Scutellaria baicalensis Georgi is one of the important medicinal herbs widely used for the treatment of various inflammatory diseases in Asia. Baicalin (BA) is a bioactive anti-inflammatory flavone found abundantly in Scutellaria baicalensis Georgi.
Y. Zeng, C. Song, X. Ding, X. Ji, L. Yi, K. Zhu   +5 more
doaj