Results 131 to 140 of about 6,369,773 (275)

Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis

Immunology Letters, 2014
Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system (CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the CNS.
Zhi-Long Jiang, Jack Jiang, Guang-Xian Zhang   +2 more
semanticscholar   +1 more source

Inosina previne a resposta inflamatória e nociceptiva induzida pelo modelo experimental de esclerose múltipla [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2015.A Esclerose Múltipla (EM) é uma doença autoimune mediada por linfócitos T e caracterizada por ...
Junqueira, Stella Célio
core  

Dietary carnosine intake improves outcomes in Experimental Autoimmune Encephalomyelitis

, 2019
Background: Carnosine (C9H14N4O3) is a naturally occurring dipeptide synthetized from histidine and β-alanine that is mainly found in excitable tissues such as skeletal muscle and the central nervous system (CNS).
Vanmierlo, T, Eijnde, BO, Franssen, W, Bogie, J, Derave, W, Spaas, J   +5 more
core   +1 more source

Regulation of Fas mediated apoptosis by CD44 [PDF]

, 2005
Over the last decade, apoptosis has grown from an obscure process to a complex and interesting scientific field, and many players have been identified.
Mielgo Iza, Ainhoa
core   +1 more source

Early tocilizumab and outcomes in acute necrotizing encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Early tocilizumab and outcome in acute necrotising encephalopathy. Aim To evaluate the timing and safety of tocilizumab in acute necrotizing encephalopathy (ANE). Method This was a multicentre retrospective study evaluating outcomes (modified Rankin Scale [mRS]) in children with ANE treated with tocilizumab. A logistic regression model determined a cut‐
Velda X Han, Prithuja Poudyal, Vanessa Lee, Arushi Gahlot Saini, Shekeeb S Mohammad, Sekhar C Pillai, Gouri Rao Passi, Naveen Sankhyan, Ahmad Rithauddin Mohamed, Lokesh Lingappa, Hiroshi Sakuma, Russell C Dale, Ming Lim, Terrence Thomas, for The International ANE Study Group   +14 more
wiley   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2014
Chemokine (C-C motif) ligand 2 (CCL2), initially identified as monocyte chemoattractant protein-1 (MCP-1), recruits immune cells to the central nervous system (CNS) during autoimmune inflammation.
Roy Y. Kim, Alexandria Hoffman, N. Itoh, Y. Ao, R. Spence, M. Sofroniew, R. Voskuhl   +6 more
semanticscholar   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Calvarial Bone Channels and a Putative Craniomaxillary–Brain Interface in Central Nervous System Immunity

Med Research, EarlyView.
Ziwen Sheng, Yulong Zhang, Hao Wang, Wenyu Zhen, Youming Zhu, Haitao Wang, Hengguo Zhang   +6 more
wiley   +1 more source