Results 141 to 150 of about 2,734 (194)

Copolymer 1 inhibits experimental autoimmune uveoretinitis

Journal of Neuroimmunology, 2000
Copolymer 1 (Cop 1) inhibits experimental allergic encephalomyelitis induced by a variety of myelin proteins, but has been found ineffective so far in inhibiting other experimental autoimmune diseases such as diabetes or arthritis. Here, we report for the first time that Cop I inhibits the development of experimental autoimmune uveoretinitis, induced ...
M, Zhang, C C, Chan, B, Vistica, V, Hung, B, Wiggert, I, Gery   +5 more
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Pathology of experimental autoimmune uveoretinitis in mice

Journal of Autoimmunity, 1990
The histopathology and immunopathology of murine experimental autoimmune uveoretinitis (EAU) following active immunization with the interphotoreceptor retinoid-binding protein (IRBP) were studied. The methods used included conventional light microscopy and immunoperoxidase staining.
C C, Chan, R R, Caspi, M, Ni, W C, Leake, B, Wiggert, G J, Chader, R B, Nussenblatt   +6 more
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Antigen-presenting Cells in Experimental Autoimmune Uveoretinitis

Experimental Eye Research, 1998
The present study attempts to identify the antigen-presenting cells in the retina, utilizing bone marrow-transplanted chimeric rats. Two types of chimeras were used: one produced by transplanting bone marrow cells from F1 hybrids of Lewis and Brown Norway (BN) into sublethally irradiated Brown Norway rats (LBN/F1-->BN), followed by adoptive transfer of
S, Ishimoto, J, Zhang, V K, Gullapalli, G, Pararajasegaram, N A, Rao   +4 more
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Angiography of experimental autoimmune uveoretinitis with ultrastructural correlation

Graefe's Archive for Clinical and Experimental Ophthalmology, 1998
Indocyanine green (ICG) angiography has been used to evaluate posterior uveitis in the clinical setting, despite the shortage of data on possible pathological correlates of observed findings.We used both ICG angiography and fluorescein angiography to examine rats that developed a mild form of experimental autoimmune uveoretinitis (EAU) induced by ...
A A, Okada, H, Goto, T, Mizusawa, K, Morimoto, Y, Ebihara, M, Usui   +5 more
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Experimental autoimmune uveoretinitis: idiotypic regulation and disease suppression

International Ophthalmology, 1990
Experimental autoimmune uveoretinitis (EAU), a mostly T-cell dependent disease, was induced in laboratory animals by a single immunization with retinal extract or purified S-antigen in complete Freund's adjuvant. It can be prevented or suppressed by injections of either the autoantigen or monoclonal antibodies against the autoantigen.
Y, De Kozak, M, Mirshahi
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Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis

Japanese Journal of Ophthalmology, 1997
Tacrolimus and rapamycin both belong to a new family of immunosuppressants, immunophilin ligands, but the mechanisms by which they inhibit T cell activation are different. Therefore, we tested the immunosuppressive effects of combination therapy with low doses of tacrolimus and rapamycin on experimental autoimmune uveoretinitis (EAU) in rats.
E, Ikeda, N, Hikita, K, Eto, M, Mochizuki   +3 more
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Rhodopsin-induced experimental autoimmune uveoretinitis: Dose-dependent clinicopathological features

Experimental Eye Research, 1988
We have studied the clinicopathological features of experimental autoimmune uveoretinitis (EAU) induced in Lewis rats by injection of different doses of rhodopsin and its illuminated form opsin. Rhodopsin consistently appears to be more pathogenic than opsin.
J J, Schalken, H J, Winkens, A H, van Vugt, P H, Bovée-Geurts, W J, de Grip, R M, Broekhuyse   +5 more
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Effect of Sex Hormones on Experimental Autoimmune Uveoretinitis (EAU)

Immunological Investigations, 2003
Sex hormones have been associated with the prevalence, susceptibility, and severity of autoimmune disease. Although the exact mechanism is unknown, sex hormones are reported to influence cytokine production, specifically by affecting the balance of Th1 and Th2 effector cells.
Ronald R, Buggage, Dawn M, Matteson, De Fen, Shen, Bing, Sun, Nadine, Tuaillon, Chi-Chao, Chan   +5 more
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Retinal Leukocyte Behavior in Experimental Autoimmune Uveoretinitis of Rats

Experimental Eye Research, 1997
In vivo retinal leukocyte behavior in the experimental autoimmune uveoretinitis (EAU) of rats was investigated using acridine orange digital fluorography. The technique employed high resolution images obtained from a scanning laser ophthalmoscope (SLO) subsequent to staining with the fluorescent nuclear dye, acridine orange.
M, Hamada, Y, Ogura, K, Miyamoto, H, Nishiwaki, N, Hiroshiba, Y, Honda   +5 more
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Experimental Autoimmune Uveoretinitis in the Rat and Mouse

Current Protocols in Immunology, 2003
AbstractExperimental autoimmune uveoretinitis (EAU) in rats and mice is a prototypic T cell‐mediated autoimmune disease that targets the neural retina and related tissues. The model is used to represent human sight‐threatening inflammatory eye diseases that are believed to have an autoimmune etiology, and to study basic mechanisms of tolerance and ...
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