Results 121 to 130 of about 6,570,481 (314)

Performance and eye movement patterns of industrial design students reading sustainable design articles

Scientific Reports
Sustainable design education plays a crucial role in cultivating sustainability awareness and competencies among students studying industrial design. This research investigates their sustainability levels, reading performance when engaging with articles,
Yongchun Mao, Yanjun Han, Puhong Li, Chengming Si, Dan Wu   +4 more
doaj   +1 more source

Controlled Experimentation in Naturalistic Mobile Settings

, 2013
Performing controlled user experiments on small devices in naturalistic mobile settings has always proved to be a difficult undertaking for many Human Factors researchers.
Chen, Tianyi, Harper, Simon, Yesilada, Yeliz   +2 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

INTELLIGENT ASSISTED/CONTROLLED MECHANICAL VENTILATION (A/C MV) AUTOMATION SYSTEM DESIGNED FOR AN EXPERIMENTAL ARTIFICIAL VENTILATION DEVICE

, 2023
Andrei Mitru, Adrian Stoicescu, Daniel Lale, Remus Stoica, Mihaela Roman, Mihai Popescu, Guillermo Bugedo, Jaime Retamal, Alejandro Bruhn, Heather Baid, Luciano Gattinoni, Jean Arnal, Michel, Matthias Van Der Staay, Robert Chatburn, Diego Casali, R Chatburn, M Khatib, E Mireles-Cabodevila, Ryan Mcconnell, Pascal Reper, J Scott, Brady, Dhan Shrestha, Bahadur, Spadaro, Savino, Lynn Rutsaert, Xianyong Li, Leonardo Acho, Alessandro Vargas, Gisela Pujol-Vzquez, Van Gassel, J Rob, Ajay Gautam, Prashad, Nitipong Permpalung, Raminder Aul   +37 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Original Research: Descriptive or Analytical, Either-Or or Both-And?

Philippine Journal of Otolaryngology Head and Neck Surgery
descriptive (adj.) “serving or aiming to describe,” 1751, from Late Latin descriptivus, from descript-, past-participle stem of describere “to write down, copy; sketch, represent,” from de “down” (see de-) + scribere “to write” (from PIE root *skribh- “
José Florencio Lapeña
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Does size really matter? Effects of experimental unit size and relative humidity on the life-history parameters of yellow mealworm

Animal
Given the relative novelty of the research in insects as food and feed, experiment protocols often differ among each other, rendering comparison difficult.
A. Resconi, Z. Loiotine, S. Bellezza Oddon, I. Biasato, L. Gasco   +4 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source