Results 151 to 160 of about 23,778,628 (351)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Experimental Design for Sensitivity Analysis of Simulation Models [PDF]

This introductory tutorial gives a survey on the use of statistical designs for what if-or sensitivity analysis in simulation.This analysis uses regression analysis to approximate the input/output transformation that is implied by the simulation model ...
Kleijnen, J.P.C.
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Nfluence of the concrete joint on the spacer system of the excavation under accidental impact

Stroitel’stvo: Nauka i Obrazovanie
Introduction. Due to the increasing use of underground space in cities, deeper excavations are increasingly being used. These excavations contain more elements and increase the chance of failure of one of the elements. When excavations collapse, there is
A. V. Isaev
doaj   +1 more source

Consensus for experimental design in electromyography (CEDE) project: Amplitude normalization matrix.

Journal of Electromyography & Kinesiology, 2020
M. Besomi, Paul W. Hodges, Edward A. Clancy, Jaap H van Dieën, François Hug, Madeleine Lowery, Roberto Merletti, Karen Søgaard, T. Wrigley, T. Besier, Richard G. Carson, Cathy Disselhorst-Klug, R. Enoka, Deborah Falla, Dario Farina, S. Gandevia, A. Holobar, Matthew C Kiernan, K. McGill, Eric J. Perreault, J. C. Rothwell, K. Tucker   +21 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Graphic Restitution and Recovery of the Chronos Pavement of the Marquis of Benicarlo’s House

Heritage
The Marquis of Benicarlo’s House is a prime example of 18th-century Baroque civil architecture in the Valencian region. Inside, it preserves ceramic panels from this period of great historical and heritage value.
Joaquín A. Martínez-Moya, Jaume Gual-Ortí   +1 more
doaj   +1 more source

Design of an Experimental‐Model Formant Vocoder [PDF]

, 1963
Robert A. Houde, Wilbur D. Larkin, Leslie C. Stewart   +2 more
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Examining behaviour change techniques (BCTs) in technology-based interventions for enhancing social participation in people with mild cognitive impairment (MCI) or dementia: a scoping review protocol

BMJ Open
Introduction Technology-based interventions have improved the social participation of older adults with mild cognitive impairment (MCI) or dementia. Nevertheless, how these interventions modify social participation remains to be seen, and what efficient ...
Wei Liu, Abdullah Al Mahmud, Di Zhu
doaj   +1 more source