Results 71 to 80 of about 23,725,775 (352)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
The Perils of Balance Testing in Experimental Design: Messy Analyses of Clean Data
, 2019 Widespread concern over the credibility of published results has led to scrutiny of statistical practices. We address one aspect of this problem that stems from the use of balance tests in conjunction with experimental data.
Diana C. Mutz +2 more
semanticscholar +1 more source
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1959 Summary After some introductory remarks, we discuss certain basic considerations such as the nonoptimality of the classical symmetric (balanced) designs for hypothesis testing, the optimality of designs invariant under an appropriate group of transformations, etc. In section 3 we discuss complete classes of designs, while in section 4 we
openaire +2 more sources
Experimental and Quasi-Experimental Designs
, 2011 In strengthening social work’s ability to improve lives and communities, experimental design can play a critical role in helping stakeholders better understand what works in achieving positive impacts. Experimental design studies aim to test whether a specific “intervention” (or “treatment”) causes change in specific outcomes. Experiments test for this
Matthew Morton, Paul Montgomery
openaire +1 more source
Panel Data and Experimental Design [PDF]
SSRN Electronic Journal, 2017 How should researchers design experiments to detect treatment effects with panel data? In this paper, we derive analytical expressions for the variance of panel estimators under non-i.i.d. error structures, which inform power calculations in panel data settings.
Fiona Burlig +2 more
openaire +4 more sources
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Industry & higher education, 2018 True experimental design and quasi-experimental design are considered to be rigorous research designs appropriate for assessing the impact of pedagogical interventions.
Kjersti Kjos Longva, L. Foss
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Sparsely Sampling the Sky: A Bayesian Experimental Design Approach
, 2012 The next generation of galaxy surveys will observe millions of galaxies over large volumes of the universe. These surveys are expensive both in time and cost, raising questions regarding the optimal investment of this time and money.
Jaffe, A. H., Paykari, P.
core +2 more sources
New Glass Design Approaches Developed During an Experimental Student Workshop
Challenging Glass Conference Proceedings, 2010 During two semesters the ILEK (Institute for Lightweight Structures and Conceptual Design) held an explorative student workshop focusing on new glass design possibilities.
Kerstin Puller +4 more
doaj +1 more source