Results 101 to 110 of about 4,723,194 (346)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study of synthesis parameters of MIL-53(Al) using experimental design methodology for CO/CH separation

Adsorption Science & Technology, 2018
In this study hydrothermal method was used to synthesize MIL-53(Al) (MIL stands for Materials Institute of Lavoisier). Plackett–Burman (P–B) as an experimental design method was applied to investigate the effect of synthesis and activation conditions on ...
Armin Taheri, Ensieh Ganji Babakhani, Jafar Towfighi   +2 more
doaj   +1 more source

Experiences and Senses: An Experimental Based Methodology for the Design Optimization

, 2014
Understanding users’ points of view is rapidly becoming an urgent issue for companies and designers, as well as User Experience and Experience Design proving to be of wide interest for academic research. This paper presents an experimental-based methodology aimed at guiding designers during product optimisation.
GATTI, ELIA, BORDEGONI, MONICA, CAMERE, SERENA   +2 more
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Integration of Design of Experiments, Analysis of Variance and Response Surface Methodology in Assessing Heterogeneous Catalysts Processes: A Minireview

ChemistryOpen
This work reviews the application of Analysis of Variance (ANOVA), Design of Experiments (DOE), and Response Surface Methodology (RSM) in heterogeneous catalysis, based on an analysis of recent scientific literature.
Carlos Esteban Aristizábal‐Alzate, Eva Castillejos‐López, Ana Belén Dongil, Manuel Romero‐Sáez   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design Methodology for LED Lighting Systems Based on Photo-Electro-Thermal Interrelationships

Eletrônica de Potência, 2018
This paper presents a design methodology for LED (Light-Emitting Diode) lighting systems based on photo-electro-thermal (PET) interrelationships. The proposed methodology uses only LED datasheet information, which makes experimental tests unnecessary to
Leandro Chies, Maicol F. de Melo, William D. Vizzotto, Rudimar Spannemberg Jr., Vitor C. Bender, Marco A. Dalla Costa   +5 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Swarm-Based Spatial Sorting

, 2008
Purpose: To present an algorithm for spatially sorting objects into an annular structure. Design/Methodology/Approach: A swarm-based model that requires only stochastic agent behaviour coupled with a pheromone-inspired "attraction-repulsion" mechanism ...
Amos, Martyn, Don, Oliver
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source