Results 121 to 130 of about 4,723,194 (346)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Utilizing experimental design and desirability function in optimizing RP-HPLC method for simultaneous determination of some skeletal muscle relaxants and analgesics

Scientific Reports
An experimental design and response surface methodologies using Plackett–Burman and Box-Behnken designs were applied for selecting and optimizing the most appropriate parameters which significantly affect the separation and quantitative estimation of ...
Ayoub N. Mozayad, Marwa A. Fouad, Ehab F. Elkady   +2 more
doaj   +1 more source

Unraveling the temperature dependence of the yield strength in single-crystal tungsten using atomistically-informed crystal plasticity calculations

, 2015
We use a physically-based crystal plasticity model to predict the yield strength of body-centered cubic (bcc) tungsten single crystals subjected to uniaxial loading.
Ackermann, Alankar, Ali, Argon, Arieli, Arsenlis, Barton, Basinski, Bodner, Bowden, Brinckmann, Brunner, Brunner, Brünig, Bulatov, Bulatov, Cai, Caillard, Caillard, Caillard, Cereceda, Cereceda, Chang, Chaussidon, Chen, Christensen, Christian, Dao, David Cereceda, Deo, Dezerald, Dezerald, Dierk Raabe, Dorn, Drucker, Duesbery, Duesbery, Duesbery, Dumoulin, Erieau, Escaig, Escaig, Estrin, Fish, Franciosi, Franciosi, Franciosi, Franz Roters, Gilbert, Gordon, Gröger, Gröger, Gröger, Gröger, Gröger, Gupta, Hamelin, Hedworth, Henkelman, Hull, Hutchinson, Hölscher, Hölscher, Ito, J. Manuel Perlado, Jaime Marian, Kalidindi, Kitayama, Klopp, Knezevic, Kocks, Koester, Komanduri, Kuchnicki, Lee, Lee, Li, Lim, Lim, Lim, Lin, Lubliner, Ma, Madec, Marichal, Marichal, Martin Diehl, McDowell, Mecking, Monnet, Monnet, Naamane, Narayanan, Pariseau, Patra, Peeters, Pichl, Plimpton, Prager, Proville, Qin, Queyreau, Queyreau, Raabe, Raabe, Raabe, Raffo, Raphanel, Reina, Romaner, Roters, Roters, Roters, Samolyuk, Scarle, Schmid, Seeger, Seeger, Serenelli, Sheng, Sherwood, Soare, Stainier, Starovoitov, Stephens, Stukowski, Swinburne, Takeuchi, Tang, Taylor, Taylor, Taylor, Taylor, Ventelon, Ventelon, Vitek, Vitek, Weinberger, Weinberger, Woodward, Wurster, Yalcinkaya, Yang, Zurek, Zwiesele, Šesták   +145 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

The application of experimental design models in order to optimize the synthesis of geopolymers

MATEC Web of Conferences, 2018
The aim of this work is to propose the methodology and the mathematical tools for the design and development of geopolymeric materials from industrial wastes and by-products.
Kioupis Dimitris, Skaropoulou Aggeliki, Tsivilis Sotiris, Kakali Glikeria   +3 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

DO AUCTION BIDS BETRAY EXPECTATIONS-BASED REFERENCE DEPENDENT PREFERENCES? A TEST, EXPERIMENTAL EVIDENCE, AND ESTIMATES OF LOSS AVERSION [PDF]

In this paper, we provide a novel experimental auction design that exploits an exogenous variation in the probability of winning to test for the presence of expectations-based reference dependent preferences. We prove that (i) in this design, (which is a
A. BANERJI, NEHA GUPTA
core