Results 131 to 140 of about 634,607 (352)

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Experimental and Spontaneous Diabetes in Animals: What is Their Relevance to Human Diabetes Mellitus? [PDF]

, 1971
Albert E. Renold, Ian M. Burr, W. Stauffacher   +2 more
openalex   +1 more source

Efecto hipoglucemiante de un alimento funcional a base de lenteja y aceite de capulín, sobre un modelo experimental murino con diabetes mellitus tipo 2.

, 2021
Iridia CHÁVEZ LARIOS, Odeth Marcelina SOTO QUINTANA, Rafael ORTIZ ALVARADO   +2 more
openalex   +2 more sources

ANALISIS EFEKTIVITAS BIAYA TERAPI KOMBINASI ANTIHIPERTENSI PADA PASIEN HIPERTENSI KOMPLIKASI DIABETES MELLITUS TIPE 2 PASIEN RAWAT INAP DI RSI AISYIYAH KOTA MALANG [PDF]

Background: Hypertension and diabetes mellitus are interrelated diseases that affect an individual to be atherosclerotic disease. Hypertension is also associated with 30% mortality in patients with diabetes mellitus.
Rusyidah, Fakhriyah Iklil
core  

The anti-atherogenic effects of thiazolidinediones [PDF]

, 2007
The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced
Honisett, Suzy, Komesaroff, Paul A, Stojanovska, Lily   +2 more
core  

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

The Effect of Nano-Epigallocatechin-Gallate on Oxidative Stress and Matrix Metalloproteinases in Experimental Diabetes Mellitus. [PDF]

Antioxidants (Basel), 2020
Bulboaca AE, Boarescu PM, Porfire AS, Dogaru G, Barbalata C, Valeanu M, Munteanu C, Râjnoveanu RM, Nicula CA, Stanescu IC.   +9 more
europepmc   +1 more source

AN EXPERIMENTAL STUDY TO ASSESS THE EFFECTIVENESS OF BUERGER ALLEN EXERCISE ON LOWER EXTREMITY PERFUSION AMONG PATIENTS WITH DIABETES MELLITUS IN CIVIL HOSPITAL AND A SELECTED PRIMARY HEALTH CENTRE AT FATEHABAD IN HARYANA

, 2022
Ms. Neeraj neeraj, M. G.
openalex   +1 more source

The Effectiveness of Life Skills Training on Cognitive Flexibility and Quality of Life in Elderly People with Diabetes Mellitus Type-2: A Quasi-Experimental Study [PDF]

, 2023
Fatemeh Heidari, Reza Mottaghi
openalex   +1 more source