Results 91 to 100 of about 751,176 (305)

Experimental evolution of aging in a bacterium [PDF]

BMC Evolutionary Biology, 2007
BMC Evolutionary Biology ...
Ackermann, M., Schauerte, A., Stearns, S. C., Jenal, U.   +3 more
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Evolutionary transitions during RNA virus experimental evolution [PDF]

, 2016
[EN] In their search to understand the evolution of biological complexity, John Maynard Smith and Eors Szathmary put forward the notion of major evolutionary transitions as those in which elementary units get together to generate something new, larger ...
Elena Fito, Santiago Fco
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of hosts on competition among clones and evidence of differential selection between pathogenic and saprophytic phases in experimental populations of the wheat pathogen Phaeosphaeria nodorum

BMC Evolutionary Biology, 2011
Background Monoculture, multi-cropping and wider use of highly resistant cultivars have been proposed as mechanisms to explain the elevated rate of evolution of plant pathogens in agricultural ecosystems.
Mascher Fabio, McDonald Bruce A, Sommerhalder Rubik J, Zhan Jiasui   +3 more
doaj   +1 more source

Species dynamics in natural bacterial communities over multiple rounds of propagation

Evolutionary Applications, 2022
Our experimental work illustrates how microbial ecosystems can be shaped by selective pressures over long‐term ecological time scales. Natural microbial ecosystems generally consist of various co‐existing species, where community composition describes ...
Anneloes E. Groenenboom, Joost van denHeuvel, Bas J. Zwaan, Eddy J. Smid, Sijmen E. Schoustra   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Stress adaptation under in vitro evolution influences survival and metabolic phenotypes of clinical and environmental strains of Vibrio cholerae El-Tor

Microbiology Spectrum
Bacterial adaptation to stress can lead to phenotypic variants with diverse levels of niche competitiveness, pathogenicity, and antimicrobial resistance.
Nana Eghele Adade, Stephen Dela Ahator, Inmaculada García-Romero, Macarena Algarañás, Vincent Appiah, Miguel A. Valvano, Samuel Duodu   +6 more
doaj   +1 more source

Potential for Acanthoscelides obtectus to Adapt to New Hosts Seen in Laboratory Selection Experiments

Insects, 2019
Effective pest management strategies for a targeted pest species must rely on accurate, reliable and reproducible estimates of population dynamics. Importance of such approaches is even more conspicuous when assessing pest’s potential to utilize ...
Uroš Savković, Mirko Đorđević, Biljana Stojković   +2 more
doaj   +1 more source