Results 71 to 80 of about 751,176 (305)

Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease

eLife, 2022
The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2, which affect protein N-linked glycosylation. The yeast gene SEC53 encodes a homolog of human PMM2. We evolved 384 populations of
Ryan C Vignogna, Mariateresa Allocca, Maria Monticelli, Joy W Norris, Richard Steet, Ethan O Perlstein, Giuseppina Andreotti, Gregory I Lang   +7 more
doaj   +1 more source

Cancer in Light of Experimental Evolution [PDF]

Current Biology, 2012
Cancer initiation, progression, and the emergence of therapeutic resistance are evolutionary phenomena of clonal somatic cell populations. Studies in microbial experimental evolution and the theoretical work inspired by such studies are yielding deep insights into the evolutionary dynamics of clonal populations, yet there has been little explicit ...
Sprouffske K, Merlo LM, Gerrish PJ, Maley CC, Sniegowski PD   +4 more
openaire   +3 more sources

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Benthic diel oxygen variability and stress as potential drivers for animal diversification in the Neoproterozoic-Palaeozoic

Nature Communications
The delay between the origin of animals in the Neoproterozoic and their Cambrian diversification remains perplexing. Animal diversification mirrors an expansion in marine shelf area under a greenhouse climate, though the extent to which these ...
Emma U. Hammarlund, Anuraag Bukkuri, Magnus D. Norling, Mazharul Islam, Nicole R. Posth, Etienne Baratchart, Christopher Carroll, Sarah R. Amend, Robert A. Gatenby, Kenneth J. Pienta, Joel S. Brown, Shanan E. Peters, Kasper Hancke   +12 more
doaj   +1 more source

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

eLife, 2016
Due to their strict maternal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutations that are beneficial or neutral in females but harmful in males.
Maulik R Patel, Ganesh K Miriyala, Aimee J Littleton, Heiko Yang, Kien Trinh, Janet M Young, Scott R Kennedy, Yukiko M Yamashita, Leo J Pallanck, Harmit S Malik   +9 more
doaj   +1 more source

Experimental evolution of immunological specificity [PDF]

Proceedings of the National Academy of Sciences, 2019
Memory and specificity are hallmarks of the adaptive immune system. Contrary to prior belief, innate immune systems can also provide forms of immune memory, such as immune priming in invertebrates and trained immunity in vertebrates. Immune priming can even be specific but differs remarkably in cellular and molecular functionality from the well-studied
Kevin Ferro, Robert Peuß, Wentao Yang, Philip Rosenstiel, Hinrich Schulenburg, Joachim Kurtz   +5 more
openaire   +3 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Impact of timely vaccination and genomic surveillance on controlling consecutive waves of SARS-CoV-2 variants

Scientific Reports
During the global COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOCs) emerged, causing massive transmission waves that affected infection outcomes, economies and public health.
Cecilia Salazar, Nídia S. Trovão, Ignacio Ferrés, Alicia Costábile, Mercedes Paz, Paula Perbolianachis, Ana Moller, Viviana Bortagaray, Rodney Colina, Natalia Rego, Tamara Fernandez-Calero, Lucia Spangenberg, Bernardina Rivera, Martina Alonso, Matías Maidana, Interinstitutional Working Group, Gregorio Iraola, Gonzalo Moratorio, Pilar Moreno   +18 more
doaj   +1 more source

Physiology of Highly Radioresistant Escherichia coli After Experimental Evolution for 100 Cycles of Selection

Frontiers in Microbiology, 2020
Ionizing radiation (IR) is lethal to most organisms at high doses, damaging every cellular macromolecule via induction of reactive oxygen species (ROS).
Steven T. Bruckbauer, Joel Martin, Benjamin B. Minkoff, Benjamin B. Minkoff, Mike T. Veling, Illissa Lancaster, Jessica Liu, Joseph D. Trimarco, Brian Bushnell, Anna Lipzen, Elizabeth A. Wood, Michael R. Sussman, Michael R. Sussman, Christa Pennacchio, Michael M. Cox   +14 more
doaj   +1 more source

Experimental evolution of bet hedging [PDF]

Nature, 2009
Bet hedging-stochastic switching between phenotypic states-is a canonical example of an evolutionary adaptation that facilitates persistence in the face of fluctuating environmental conditions. Although bet hedging is found in organisms ranging from bacteria to humans, direct evidence for an adaptive origin of this behaviour is lacking.
Beaumont, H., Gallie, J., Kost, C., Ferguson, G., Rainey, P. ; https://orcid.org/0000-0003-0879-5795   +4 more
openaire   +4 more sources