Results 81 to 90 of about 751,176 (305)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Parallel and Divergent Evolutionary Solutions for the Optimization of an Engineered Central Metabolism in Methylobacterium extorquens AM1

Microorganisms, 2015
Bioengineering holds great promise to provide fast and efficient biocatalysts for methanol-based biotechnology, but necessitates proven methods to optimize physiology in engineered strains.
Sean Michael Carroll, Lon M. Chubiz, Deepa Agashe, Christopher J. Marx   +3 more
doaj   +1 more source

Artificial Selection on Microbiomes To Breed Microbiomes That Confer Salt Tolerance to Plants

mSystems, 2021
We develop a method to artificially select for rhizosphere microbiomes that confer salt tolerance to the model grass Brachypodium distachyon grown under sodium salt stress or aluminum salt stress. In a controlled greenhouse environment, we differentially
Ulrich G. Mueller, Thomas E. Juenger, Melissa R. Kardish, Alexis L. Carlson, Kathleen M. Burns, Joseph A. Edwards, Chad C. Smith, Chi-Chun Fang, David L. Des Marais   +8 more
doaj   +1 more source

The experimental evolution of aging in fruitflies [PDF]

Experimental Gerontology, 1998
The evolutionary theory of aging suggests that the level of repair will evolve to an intermediate optimum that permits the accumulation of random damage to cells. This, in turn, causes a decline in essential functions during the life span of an organism.
Stearns SC, Ackermann M, Doebeli M
openaire   +3 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Evolution in response to prophage activation attenuates the virulence of culturable Serratia symbiotica relatives of aphid endosymbionts

mBio
Serratia symbiotica bacteria exhibit a range of relationships with aphids. They may be co-obligate mutualists, commensals, or even pathogens depending on the strain, aphid host species, and environment.
Anthony J. VanDieren, Jeffrey E. Barrick
doaj   +1 more source

Evolution of networks—an experimental analysis [PDF]

Journal of Evolutionary Economics, 2007
Published by Springer, Berlin ...
Berninghaus, S. K., Ehrhart, K.-M., Ott, M., Vogt, B.   +3 more
openaire   +2 more sources

Indirect selection of thermal tolerance during experimental evolution of Drosophila melanogaster [PDF]

, 2015
: Natural selection alters the distribution of a trait in a population and indirectly alters the distribution of genetically correlated traits. Long-standing models of thermal adaptation assume that trade-offs exist between fitness at different ...

core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source