Results 61 to 70 of about 2,596,240 (298)

EXPERIMENTAL EVOLUTION MEETS MARINE PHYTOPLANKTON [PDF]

Evolution, 2013
Our perspective highlights potentially important links between disparate fields-biological oceanography, climate change research, and experimental evolutionary biology. We focus on one important functional group-photoautotrophic microbes (phytoplankton), which are responsible for ∼50% of global primary productivity.
Thorsten B H, Reusch, Philip W, Boyd
openaire   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease

eLife, 2022
The most common cause of human congenital disorders of glycosylation (CDG) are mutations in the phosphomannomutase gene PMM2, which affect protein N-linked glycosylation. The yeast gene SEC53 encodes a homolog of human PMM2. We evolved 384 populations of
Ryan C Vignogna, Mariateresa Allocca, Maria Monticelli, Joy W Norris, Richard Steet, Ethan O Perlstein, Giuseppina Andreotti, Gregory I Lang   +7 more
doaj   +1 more source

‘The uses of ethnography in the science of cultural evolution’. Commentary on Mesoudi, A., Whiten, A. and K. Laland ‘Toward a unified science of cultural evolution’ [PDF]

, 2006
There is considerable scope for developing a more explicit role for ethnography within the research program proposed in the article. Ethnographic studies of cultural micro-evolution would complement experimental approaches by providing insights into the “
Tehrani, J.
core  

Experimental evolution of immunological specificity [PDF]

Proceedings of the National Academy of Sciences, 2019
Memory and specificity are hallmarks of the adaptive immune system. Contrary to prior belief, innate immune systems can also provide forms of immune memory, such as immune priming in invertebrates and trained immunity in vertebrates. Immune priming can even be specific but differs remarkably in cellular and molecular functionality from the well-studied
Kevin Ferro, Robert Peuß, Wentao Yang, Philip Rosenstiel, Hinrich Schulenburg, Joachim Kurtz   +5 more
openaire   +3 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Benthic diel oxygen variability and stress as potential drivers for animal diversification in the Neoproterozoic-Palaeozoic

Nature Communications
The delay between the origin of animals in the Neoproterozoic and their Cambrian diversification remains perplexing. Animal diversification mirrors an expansion in marine shelf area under a greenhouse climate, though the extent to which these ...
Emma U. Hammarlund, Anuraag Bukkuri, Magnus D. Norling, Mazharul Islam, Nicole R. Posth, Etienne Baratchart, Christopher Carroll, Sarah R. Amend, Robert A. Gatenby, Kenneth J. Pienta, Joel S. Brown, Shanan E. Peters, Kasper Hancke   +12 more
doaj   +1 more source

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

eLife, 2016
Due to their strict maternal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutations that are beneficial or neutral in females but harmful in males.
Maulik R Patel, Ganesh K Miriyala, Aimee J Littleton, Heiko Yang, Kien Trinh, Janet M Young, Scott R Kennedy, Yukiko M Yamashita, Leo J Pallanck, Harmit S Malik   +9 more
doaj   +1 more source

A photoelectron spectroscopy study of the electronic structure evolution in CuInSe2-related compounds at changing copper content [PDF]

, 2012
Evolution of the valence-band structure at gradually increasing copper content has been analysed by x-ray photoelectron spectroscopy (XPS) in In2Se3, CuIn5Se8, CuIn3Se5, and CuInSe2 single crystals. A comparison of these spectra with calculated total and
Bodnar, I. V., Derks, C., Grebennikov, V. I., Kuznetsov, M. V., Kuznetsova, T. V., Martin, R. W., Neumann, M., Persson, C., Taubitz, C., Yakushev, M. V., Zhao, H., Якушев, М. В.   +11 more
core   +1 more source

Experimental evolution of bet hedging [PDF]

Nature, 2009
Bet hedging-stochastic switching between phenotypic states-is a canonical example of an evolutionary adaptation that facilitates persistence in the face of fluctuating environmental conditions. Although bet hedging is found in organisms ranging from bacteria to humans, direct evidence for an adaptive origin of this behaviour is lacking.
Beaumont, H., Gallie, J., Kost, C., Ferguson, G., Rainey, P. ; https://orcid.org/0000-0003-0879-5795   +4 more
openaire   +4 more sources