Results 41 to 50 of about 2,596,240 (298)

Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection

eLife, 2021
Gene regulatory networks allow organisms to generate coordinated responses to environmental challenges. In bacteria, regulatory networks are re-wired and re-purposed during evolution, though the relationship between selection pressures and evolutionary ...
Vishwa Patel, Nishad Matange
doaj   +1 more source

Experimental Comparisons of Derivative Free Optimization Algorithms [PDF]

, 2009
In this paper, the performances of the quasi-Newton BFGS algorithm, the NEWUOA derivative free optimizer, the Covariance Matrix Adaptation Evolution Strategy (CMA-ES), the Differential Evolution (DE) algorithm and Particle Swarm Optimizers (PSO) are ...
D.N. Wilke, H.-P. Schwefel, K. Scheinberg, N. Hansen, N. Hansen, N. Hansen, R. Storn, V. Feoktistov, V. Torczon, Y.-W. Shang   +9 more
core   +4 more sources

Deep mutational scanning and CRISPR-engineered viruses: tools for evolutionary and functional genomics studies

mSphere
Recent advancements in synthetic biology and sequencing technologies have revolutionized the ability to manipulate viral genomes with unparalleled precision.
Mercedes Paz, Gonzalo Moratorio
doaj   +1 more source

R5 HIV‐1 envelope attracts dendritic cells to cross the human intestinal epithelium and sample luminal virions via engagement of the CCR5

EMBO Molecular Medicine, 2013
The gastrointestinal tract is a principal route of entry and site of persistence of human immunodeficiency virus type 1 (HIV‐1). The intestinal mucosa, being rich of cells that are the main target of the virus, represents a primary site of viral ...
Mariangela Cavarelli, Chiara Foglieni, Maria Rescigno, Gabriella Scarlatti   +3 more
doaj   +1 more source

On comparison of constrained and unconstrained evolutions in analogue electronics on the example of “LC” low-pass filters [PDF]

, 2006
The Evolutionary Electronics refers to the design method of electronic circuits with the help of Evolutionary Algorithms. Over the years huge experience has been accumulated and tremendous results have been achieved in this field.
Kalganova, T, Sapargaliyev, Y
core   +1 more source

Microbial Experimental Evolution as a Novel Research Approach in the Vibrionaceae and Squid-Vibrio Symbiosis

Frontiers in Microbiology, 2014
The Vibrionaceae are a genetically and metabolically diverse family living in aquatic habitats with a great propensity toward developing interactions with eukaryotic microbial and multicellular hosts (as either commensals, pathogens, and mutualists). The
William eSoto, Michele Kiyoko Nishiguchi
doaj   +1 more source

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

mBio, 2017
Staphylococcus aureus is known to generate small colony variants (SCVs) that are resistant to aminoglycoside antibiotics and can cause persistent and recurrent infections. The SCV phenotype is unstable, and compensatory mutations lead to restored growth,
Sha Cao, Douglas L. Huseby, Gerrit Brandis, Diarmaid Hughes   +3 more
doaj   +1 more source

Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance

Gut Microbes, 2023
Inflammatory bowel disease (IBD) is a persistent inflammatory condition that affects the gastrointestinal tract and presents significant challenges in its management and treatment.
Rahul Unni, Nadia Andrea Andreani, Marie Vallier, Silke S. Heinzmann, Jan Taubenheim, Martina A. Guggeis, Florian Tran, Olga Vogler, Sven Künzel, Jan-Bernd Hövener, Philip Rosenstiel, Christoph Kaleta, Astrid Dempfle, Daniel Unterweger, John F. Baines   +14 more
doaj   +1 more source

Experimental evolution with yeast [PDF]

FEMS Yeast Research, 2006
Many of the difficulties of studying evolution in action can be surmounted using populations of microorganisms, such as yeast. A readily manipulated sexual system and an increasingly sophisticated array of molecular and genomic tools uniquely qualify Saccharomyces cerevisiae as an experimental subject.
openaire   +2 more sources

Effect of a heterogeneous distribution of particles on the formation of banded grain structure in wrought Alloy 718 [PDF]

, 2005
Alloy 718 is known to be sensitive to interdendritic segregation formed during ingot solidification. The occurrence of banded grain structures under heat treating conditions close to 1000 ° C related to interdendritic segregation is often reported.
Andrieu, Eric, Coste, Sébastien, Huez, Julitte   +2 more
core   +2 more sources