Results 111 to 120 of about 11,455,032 (320)

Approaches in Post‐Experimental Science. The Case of Precision Medicine**

Berichte zur Wissenschaftsgeschichte, 2022
AbstractIn the introduction to hisSpalt und Fuge, Hans‐Jörg Rheinberger points to the possibility that we are currently experiencing a new turning point regarding forms of experimentation, which is characterized by the growing importance of high‐throughput methods and big data analytics.
openaire   +2 more sources

Opportunities From Precision Flavour Physics [PDF]

, 2009
The possible role of precision flavour physics, and particularly of B physics, in the next decade is briefly discussed. Few 2--3$\sigma$ deviations from the Standard Model found in present $B$ data are reviewed as potential forerunners of new physics ...
Ciuchini, Marco
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Método de Papadakis e número de repetições em experimentos de soja The Papadakis method and the replications number in soybean experiments

Ciência Rural, 2009
Neste trabalho, foram utilizados dados de produtividade de grãos de 216 ensaios de genótipos de soja, realizados no Estado do Rio Grande do Sul, nos anos agrícolas 2003/2004, 2004/2005 e 2005/2006. O objetivo foi verificar se o uso do método de Papadakis
Lindolfo Storck, Alberto Cargnelutti Filho, Alessandro Dal'Col Lúcio, Sidinei José Lopes   +3 more
doaj  

Productive variability, border use and plot size in trials with cherry tomato

Ciência Rural, 2018
: Knowing the productive variability within protected environments is crucial for choosing the experimental design to be used in that conditions.
Daniel Santos, Alessandro Dal’Col Lúcio, Sidinei José Lopes, Alberto Cargnelutti Filho, Tiago Olivoto   +4 more
doaj   +1 more source

The Top Priority: Precision Electroweak Physics from Low to High Energy

, 2003
Overall, the Standard Model describes electroweak precision data rather well. There are however a few areas of tension (charged current universality, NuTeV, (g-2)_\mu, b quark asymmetries), which I review emphasizing recent theoretical and experimental ...
Altarelli G., Davidson S., P. GAMBINO
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Melhoria na eficiência dos experimentos de indicalção de cultivares de milho Enhanced efficicency in experiments for maize cultivar indication

Ciência e Agrotecnologia, 2006
Objetivou-se com este trabalho verificar o comportamento da precisão experimental mediante o uso de métodos de correção de produtividade das parcelas experimentais e suas influências sobre a comparação e indicação de cultivares de milho pelo método de ...
Edilson Romais Schmildt, Willian Krause, Cosme Damião Cruz   +2 more
doaj   +1 more source

High-Precision Spectroscopy with Counter-Propagating Femtosecond Pulses

, 2013
An experimental realization of high-precision direct frequency comb spectroscopy using counter-propagating femtosecond pulses on two-photon atomic transitions is presented.
Barmes, Itan, Eikema, Kjeld S. E., Witte, Stefan   +2 more
core   +1 more source

PTEN-opathies: from biological insights to evidence-based precision medicine.

Journal of Clinical Investigation, 2019
The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN hamartoma tumor syndrome (PHTS), featuring various benign and malignant tumors, as well ...
L. Yehia, J. Ngeow, C. Eng
semanticscholar   +1 more source