Results 91 to 100 of about 3,067,916 (305)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
EXPERIMENTAL AND THEORETICAL STRESS ANALYSIS INVESTIGATION FOR COMPOSITE PLATE UNDER THERMAL LOAD
Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ, 2018 A paper focuses on the investigation of the stress-strain for E-glass fiber /polyester composite plates subjected to the uniform temperature at various factors, such as fiber volume fraction and fiber orientation.
Emad Q. Hussein, Sara J. Alasadi
doaj +1 more source
A Rayleigh-Ritz analysis methodology for cutouts in composite structures [PDF]
A new Rayleigh-Ritz stress analysis methodology that was developed for composite panels containing cutouts is described. The procedure, which makes use of a general assumed displacement field, accommodates circular and elliptical cutouts in biaxially ...
Russell, Steven G.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Analysis of delamination in unidirectional and crossplied fiber composites containing surface cracks [PDF]
A two-dimensional hybrid stress finite element analysis is described which was used to study the local stress field around delamination cracks in composite materials.
Mandell, J. F., Wang, S. S.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Pengaruh Pelatihan "Pengasuhan Ibu Cerdas" Terhadap Stres Pengasuhan Pada Ibu dari Anak Autis
Psikoislamika, 2013 Past research has shown that parents of children with autism had the highest parenting stress than parents of children with other disabilities. This study aims to determine the effect of training “pengasuhan ibu CERdaS” of parenting stress in mothers of ...
Fina Hidayati
doaj +1 more source
Deep tillage tool optimization by means of finite element method: Case study for a subsoiler tine [PDF]
, 2010 Technologies and computer capacity currently available allow us to employ design software and numerical methods to solve complicated problems in very wide disciplines of engineering. It is also important for researches in agriculture.
Akinci, Ibrahim +5 more
core