Results 71 to 80 of about 3,067,916 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Theoretical and Experimental Stress Analysis of Cam With Simple Harmonic Motion
Journal of Engineering, 2016 Cams are considered as one of the most important mechanical components that depends the contact action to do its job and suffer a lot of with drawbacks to be predicted and overcame in the design process.
Aveen Ahmed Abdulkareem, Ass. Lect.
doaj
Experimental Stress Analysis for Woven Carbon, Glass, and Kevlar Laminate Shells
Diyala Journal of Engineering Sciences, 2018 Composite shell structures have many applications in aerospace industry in which deal with various loading abundantly. In present paper Strain gauge instrument with rectangular rosette strain gauges were used to detect the maximum stress and strain ...
Azad M. A. Saber, Khatoon Y. Ibrahim
doaj +1 more source
A stress free model for residual stress assessment using thermoelastic stress analysis [PDF]
, 2014 Thermoelastic Stress Analysis (TSA) has been proposed as a method of obtaining residual stresses. The results of a preliminary study demonstrated that when Al-2024 plate containing holes that were plastically deformed by cold expansion process to 2% and ...
Achintha, Mithila +3 more
core +1 more source
Temperature robust PCA based stress monitoring approach [PDF]
, 2016 In this paper, a guided wave temperature robust PCA-based stress monitoring methodology is proposed. It is based on the analysis of the longitudinal guided wave propagating along the path under stress.
Mujica Delgado, Luis Eduardo +4 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Simulation and Experimental Validation of Stress Analysis for Train Coupler
Tikrit Journal of Engineering SciencesThis study investigates the stress distribution in a sand-cast steel train coupler by comparing experimental results with FEM simulation. Strain gauges were attached to the coupler body areas to measure stresses under varying loads ranging from 500 kN ...
Makmuri Nuramin +12 more
doaj +1 more source
Fatigue failure of materials under broad band random vibrations [PDF]
The fatigue life of material under multifactor influence of broad band random excitations has been investigated. Parameters which affect the fatigue life are postulated to be peak stress, variance of stress and the natural frequency of the system ...
Huang, T. C., Lanz, R. W.
core +1 more source
Modelling plasticity of unsaturated soils in a thermodynamically consistent framework [PDF]
, 2009 Constitutive equations of unsaturated soils are often derived in a thermodynamically consistent framework through the use a unique 'effective' interstitial pressure. This later is naturally chosen as the space averaged interstitial pressure.
Coussy, O., Pereira, Jean-Michel
core +3 more sources