Results 171 to 180 of about 9,415,293 (298)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Novel Concept and 3D Coupler for Robotic Correction of Spinal Deformities: In Vitro Experimental Testing. [PDF]

Int J Spine Surg
Elsebaie HB, Akbarnia BA, Eastlack RK, El-Hawary R, D'Lima D, Elsebaie YH, Mundis GM.   +6 more
europepmc   +1 more source

Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats. [PDF]

Nutrients, 2022
Bychkov A, Koptev V, Zaharova V, Reshetnikova P, Trofimova E, Bychkova E, Podgorbunskikh E, Lomovsky O.   +7 more
europepmc   +1 more source

Anales de la Estación Experimental de Aula Dei 15 (3-4)

, 1981
98 Págs. Índice: Incluye en preliminar obituario Don Luis-María Villena Martín (1920-1981). Índice: An analysis on the distribution of the Indian taxa of the genus Primula Linn., in the eastern Himalaya with remarks on the species of Assam / Ghosh ...
CSIC - Estación Experimental de Aula Dei (EEAD)
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Validating Numerical Simulations to Support Experimental Testing of MRI Gradient-Induced Heating of Passive Implants. [PDF]

Magn Reson Med
Zanovello U, Arduino A, Zilberti L, Schaefers G, Halaj M, Bottauscio O.   +5 more
europepmc   +1 more source

Experimental testing of air filter efficiency against the SARS-CoV-2 virus: The role of droplet and airborne transmission. [PDF]

Build Environ, 2022
Saccani C, Guzzini A, Vocale C, Gori D, Pellegrini M, Fantini MP, Primavera A.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Research and Experimental Testing of a Remotely Controlled Ankle Rehabilitation Exoskeleton Prototype. [PDF]

Sensors (Basel)
Ozhiken A, Sergazin G, Ozhikenov K, Wang H, Zhetenbayev N, Tursunbayeva G, Nurmangaliyev A, Uzbekbayev A.   +7 more
europepmc   +1 more source

Comprehensive Analysis of Steel Slag as Aggregate for Road Construction: Experimental Testing and Environmental Impact Assessment. [PDF]

Materials (Basel), 2021
Díaz-Piloneta M, Terrados-Cristos M, Álvarez-Cabal JV, Vergara-González E.   +3 more
europepmc   +1 more source