Results 181 to 190 of about 9,415,293 (298)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Experimental Testing, Manufacturing and Numerical Modelling of Composite and Sandwich Structures (Second Edition). [PDF]

Materials (Basel)
Campilho RDSG.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Experimental Testing of Host Range of the Parasitoid Wasp <i>Trichogramma dendrolimi</i> Under Laboratory Conditions. [PDF]

Insects
Ageev AA, Golovina AN, Utkuzova AM, Shestopalova AV, Tokarev YS.   +4 more
europepmc   +1 more source

Predicting Mixture Effects over Time with Toxicokinetic-Toxicodynamic Models (GUTS): Assumptions, Experimental Testing, and Predictive Power. [PDF]

Environ Sci Technol, 2021
Bart S, Jager T, Robinson A, Lahive E, Spurgeon DJ, Ashauer R.   +5 more
europepmc   +1 more source

Atomic Energy Commission Report IDO-12109

, 1961
Provides an overview of activities at the National Reactor Testing Station during ...
National Reactor Testing Station, Idaho (U.S.)
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Experimental Testing and Numerical Bite Simulation of Complete Acrylic Dentures in Eugnathic and Progenic Occlusal Relationships. [PDF]

Materials (Basel)
Pavlin M, Ćelić R, Gubeljak N, Predan J.   +3 more
europepmc   +1 more source

Experimental testing of two urban stressors on freshwater biofilms

, 2023
VRBA R, LAVOIE I, CREUSOT N, EON M, MILLAN-NAVARRO D, FEURTET-MAZEL A, MAZZELLA N, MOREIRA A, PLANAS D, MORIN S.   +9 more
europepmc   +1 more source

A Facile Synthesis Route of Hybrid Polyurea-Polyurethane-MWCNTs Nanocomposite Coatings for Ballistic Protection and Experimental Testing in Dynamic Regime. [PDF]

Polymers (Basel), 2021
Toader G, Diacon A, Rusen E, Rizea F, Teodorescu M, Stanescu PO, Damian C, Rotariu A, Trana E, Bucur F, Ginghina R.   +10 more
europepmc   +1 more source