Results 101 to 110 of about 6,543,383 (305)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2010 Truth and Verification PresentationPowerpoint Presentation of the Truth and Verification LectureTruth and Verification Presentation -- lecture8.pptxThe work(s) contained within this record have been analyzed and cataloged by members of the University ...
Stony Brook University. School of Journalism. Center for News Literacy.
core
Temporal verification in secure group communication system design [PDF]
, 2007 The paper discusses an experience in using a real-time UML/SysML profile and a formal verification toolkit to check a secure group communication system against temporal requirements.
Villemur, Thierry +7 more
core +1 more source
An Experimental Verification of the Theory of Compound Nucleus [PDF]
Physical Review, 1950 The compound nucleus ${\mathrm{Zn}}^{64}$ was formed by bombarding ${\mathrm{Ni}}^{60}$ with $\ensuremath{\alpha}$-particles and ${\mathrm{Cu}}^{63}$ with protons. The ratios of the cross sections $\ensuremath{\sigma}(\ensuremath{\alpha},n):\ensuremath{\sigma}(\ensuremath{\alpha},2n):\ensuremath{\sigma}(\ensuremath{\alpha},pn)$ for ${\mathrm{Ni}}^{60}$
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Journal of Inflammation ResearchJunping Zhu,1– 3 Ziyan Wang,4,5 Chengxin Liu,4,5 Min Shi,1,5 Zhihua Guo,1,4,5 Ya Li,2 Rong Yu,1,3 Jiaming Wei1,5 1School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2School of Pharmacy,
Zhu J +7 more
doaj