Results 121 to 130 of about 6,543,383 (305)

Truth and Verification

, 2014
Mountain climber Alex Honnold seems to defy gravity, scaling sheer, steep rock faces with no rope and apparently no fear.Truth and Verification Presentation -- lecture8.pptx Recitation: How does one verify information?
newslitstaff
core  

Analysis of thermo-hydro-mechanical coupling characteristics of artificial freezing process under seepage effects

Frontiers in Materials
The application of thermo - hydro - mechanical coupling considering seepage effects is of great significance in engineering fields such as artificial freezing.
Peipei Chen, Fengling Yin, Manqi Wang
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Experimental verification for an instrumented spherical indentation technique in determining mechanical properties of metallic materials

, 2011
A spherical indentation-based method and its numerical verification, which is capable of identifying the plastic properties, have been respectively provided by our previous work [P. Jiang, et al., J. Mater. Res. 24, 1045 (2009)] and [T. Zhang, et al., J.
Zhang, TH (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Inst Mech, Beijing 100190, Peoples R China, 杨荣, 姜鹏, 张泰华   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Rotational Order Vibration Reduction Method Using a Regular Non-Circular Pulley

Actuators
For transmission systems with regular order excitation, the order vibration will be conducted to each component of the system and affect the stability and service life of the system.
Shangbin Long, Yu Zhu, Zhihong Zhou, Fangrui Chen, Zisheng Li   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Optimization Design and Experimental Verification of the Hydrogen-Powered Self-Propelled Plant Protection Machine

Energies
The design objectives for the overall parameters of the hydrogen-powered self-propelled plant protection machine are multiple, and the constraints are complex, making it difficult for single-objective optimization methods to achieve the optimal design ...
Liyou Xu, Shuailong Hou, Yanying Li, Shenghui Lei, Mengnan Liu   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source