Results 141 to 150 of about 286,000 (316)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Research and Analysis on the Topology of a Two-Stage Electromagnetic Launch Circuit Based on Energy Recovery

IEEE Access
This study investigates a two-stage electromagnetic launch circuit based on energy recovery, focusing on the excitation circuitry utilized in an electromagnetic net launcher for its operational efficacy.
Haijun Lai, Qiang Li, Qing Lyu, Limin Li, Chunyan Liang, Huafeng Li, Yanfei Hou, Wei Zhang, Zhengyang Li   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Plans for an aeroelastic prediction workshop

, 2011
This paper summarizes the plans for the first Aeroelastic Prediction Workshop. The workshop is designed to assess the state of the art of computational methods for predicting unsteady flow fields and aeroelastic response.
Heeg, Jennifer, Florance, Jennifer, Schuster, David, Ritter, Markus, Bhatia, Kumar, Blades, Eric, Wieseman, Carol, Perry, Boyd, Mani, Mori, Boucke, Alexander, Taylor, Paul, Mavriplis, Dimitri, Smith, Marilyn, Dowell, Earl, Hansen, Thorsten, Dietz, Guido, Chwalowski, Pawel, Ballmann, Joseph, Whiting, Brent   +18 more
core  

Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease

Frontiers in Genetics
BackgroundMacrophages contribute to the immune dysregulation observed in chronic obstructive pulmonary disease (COPD). Additionally, lactylation exerts an indirect influence on COPD pathogenesis.
Hui Guo, Weilin Sun, Fang Zhao, Yang Yu, Xiaoyun Zhao, Daqiang Sun   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Conservative Stress Testing: The Role of Regular Verification

This paper focuses on how to calibrate models used to stress test the most important risks in the banking system. Based on the results of a verification of the Czech National Bank’s stress testing methodology, the paper argues that stress tests should be
Adam Gersl, Jakub Seidler
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Research and Experimental Verification of the Dynamic Pose Analysis Method of Advanced Hydraulic Support in a Fully Mechanized Mining Face

Energy Science & Engineering
This study introduces a dynamic pose analysis method for advanced hydraulic supports, driven by the hydraulic cylinder stroke. This method plays a crucial role in the precise control and path planning of the supports.
Zhang Kun, Ma Kailun, Zhang Zhaoyun, Cui Bin, Xu Yajun, Wei Xuntao, Chen Yong, Zhang Zengbao, Kong Xiangjun, Chen Hongyan, Tian Dan, Yi Ran, Du Mingchao   +12 more
doaj   +1 more source