Results 131 to 140 of about 286,000 (316)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

A Rotational Order Vibration Reduction Method Using a Regular Non-Circular Pulley

Actuators
For transmission systems with regular order excitation, the order vibration will be conducted to each component of the system and affect the stability and service life of the system.
Shangbin Long, Yu Zhu, Zhihong Zhou, Fangrui Chen, Zisheng Li   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Optimization Design and Experimental Verification of the Hydrogen-Powered Self-Propelled Plant Protection Machine

Energies
The design objectives for the overall parameters of the hydrogen-powered self-propelled plant protection machine are multiple, and the constraints are complex, making it difficult for single-objective optimization methods to achieve the optimal design ...
Liyou Xu, Shuailong Hou, Yanying Li, Shenghui Lei, Mengnan Liu   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Elucidating the multiscale mechanisms and therapeutic targets of caffeic acid in gastric cancer: a synergy of computational and experimental approaches

Frontiers in Molecular Biosciences
IntroductionGastric cancer is a malignant tumor with high incidence and mortality rates worldwide, and effective therapeutic strategies targeting its complex pathological processes are limited.
Hongrong Zhang, Yufan Li, Ya Li
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Experimental verification of field-enhanced molecular vibrational scattering at single infrared antennas -- Dataset

nano-FTIR data is provided as interferogram files ending in "Interferograms.txt.txt" within the individual folders containing the string "NF S". Row: not used Column: not used Run: number of interferogram acquisition Depth: pixel number within one ...
Schnell, Martin, Virmani, Divya, Maciel-Escudero, Carlos, Hillenbrand, Rainer   +3 more
core   +1 more source

Mendelian randomization combined with single-cell sequencing analysis revealed prognostic genes related to myeloid cell differentiation in prostate cancer and experimental verification

Frontiers in Immunology
BackgroundMyeloid cell differentiation (MCD) has an important correlation with prostate cancer (PCa), but the mechanism of action of the former in the latter is still under investigation. This study designed to investigate the prognostic genes related to
Jianbai Chen, Jianxin Qiu, Wei Zhang, Zhiyong Nie, Xiaoping Gao, Gongquan Xu, Leiming Kang, Zhiming Zhang   +7 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source