Results 61 to 70 of about 1,148,036 (286)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Heterogeneous integrated dataset for Maritime Intelligence, surveillance, and reconnaissance
Data in Brief, 2019 Facing an ever-increasing amount of traffic at sea, many research centres, international organisations, and industrials have favoured and developed sensors together with detection techniques for the monitoring, analysis, and visualisation of sea ...
Cyril Ray +4 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Studies on thermo-oxidative degradation of synthetic rubbers 1-4 and 1-2 polybutadienes
Vietnam Journal of Science, Technology and Engineering, 2017 The production of natural latex is limited, and the related demand for terrestrial transportation has increased. The synthesis of rubber has become necessary and the resulting synthetics’ properties must be known.
Quoc Hung Nguyen +3 more
doaj +1 more source
Вестник Северо-Кавказского федерального университета, 2022 The article deals with the concept of «analytical skills». The authors substantiate that the method of experimentation can act as a pedagogical tool in the development of analytical skills in students, since it is aimed at the development of thought ...
L. Saenko, G. Solomatina
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Technology Assessment and Experimentation Plan [PDF]
, 1990 An assessment is given of the critical and enhancing technologies necessary to build the basic personal terminal (BPT), the supplier, and the Network Management Center (NMC). The experimentation plan for testing the Personal Access Satellite System (PASS)
Estabrook, Polly
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
BioMedical Engineering OnLineThe degeneration of the intervertebral discs in the lumbar spine is the common cause of neurological and physical dysfunctions and chronic disability of patients, which can be stratified into single—(e.g., disc herniation, prolapse, or bulge) and ...
Ichiro Nakamoto +6 more
doaj +1 more source