Results 91 to 100 of about 2,159,559 (302)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Revista Sociedade, Contabilidade e Gestão, 2013 The number of processes that demand accounting expertise is growing. In the expertise process occur several steps of communication among judges, lawyers, related parts and expert accountant.
Vanderlei dos Santos +3 more
doaj
Expert system technology [PDF]
The expert system is a computer program which attempts to reproduce the problem-solving behavior of an expert, who is able to view problems from a broad perspective and arrive at conclusions rapidly, using intuition, shortcuts, and analogies to previous ...
Prince, Mary Ellen
core +1 more source
The Journey Continues: Ensuring a Cross-Culturally Competent Evaluation [PDF]
, 2009 Follows up the 2007 report The Importance of Culture in Evaluation with scenarios of how cross-cultural issues emerge and expert commentary on how to address them.
Kien Lee, Nancy B. Csuti
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Global Entrepreneurship Monitor : United Kingdom 2009 Monitoring Report [PDF]
, 2010 This monitoring report compares Global Entrepreneurship Monitor (GEM) measures of entrepreneurial attitudes and activity in the UK and participating G7 and BRIC countries.
Hart, Mark, Levie, Jonathan
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Report of the 5th European expert meeting on rotavirus vaccination (EEROVAC)
Human Vaccines & Immunotherapeutics, 2018 The Fifth European Expert Meeting on Rotavirus Vaccination was convened in Utrecht, The Netherlands, in March 2017. The 2-day meeting included invited lectures as well as original oral and poster presentations and brought together experts from 21 ...
Marieke L. A. de Hoog +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source