Results 91 to 100 of about 10,014,817 (250)

A systematic review of the applications of Expert Systems (ES) and machine learning (ML) in clinical urology. [PDF]

BMC Med Inform Decis Mak, 2021
Salem H, Soria D, Lund JN, Awwad A.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An extended query-the-user tool for expert systems

, 1998
An extended version of HIER, a query-the-user facility for expert systems is presented. HIER was developed to run over Prolog programs, and has been incorporated to systems that support the design of large and complex applications.
de Sena, G. J., Furtado, A. L., Cantu, F. J., Liebowitz, J., Sucar, E., Soto, R.   +5 more
core   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

HUMAN-RESOURCE MANAGEMENT EXPERT-SYSTEMS TECHNOLOGY

, 1994
This paper provides human resource managers with important guidelines when applying expert systems to human resource domains, by reviewing system characteristics, potential benefits and limitations, and appropriate domains to be selected, based on the ...
SUH, EH, Eui‐Ho Suh, BYUN, DH, Dae‐Ho Byun   +3 more
core   +1 more source

End-to-end IoT sensor data simulation and predictive analysis: framework implementation and experimental evaluation

Scientific Reports
The rapid expansion of the Internet of Things (IoT) has led to an exponential increase in sensor-generated data, creating challenges for efficient data management and transmission.
Darlan Noetzold, Valderi Reis Quietinho Leithardt, Juan Francisco de Paz, Jorge Luis Victória Barbosa   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

PSYCH—Psychometric Assessment of Large Language Model Characters: An Exploration of the German Language

Analytics
Background: Existing evaluations of large language models (LLMs) largely emphasize linguistic and factual performance, while their psychometric characteristics and behavioral biases remain insufficiently examined, particularly beyond English-language ...
Nane Kratzke, Niklas Beuter, André Drews, Monique Janneck   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source