Results 111 to 120 of about 10,014,817 (250)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Methodology Based on Expert Systems for the Early Detection and Prevention of Hypoxemic Clinical Cases. [PDF]

Int J Environ Res Public Health, 2020
Comesaña-Campos A, Casal-Guisande M, Cerqueiro-Pequeño J, Bouza-Rodríguez JB.   +3 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Advanced Machine Learning and Deep Learning Approaches for Estimating the Remaining Life of EV Batteries—A Review

Batteries
This systematic review presents a critical analysis of advanced machine learning (ML) and deep learning (DL) approaches for predicting the remaining useful life (RUL) of electric vehicle (EV) batteries.
Daniel H. de la Iglesia, Carlos Chinchilla Corbacho, Jorge Zakour Dib, Vidal Alonso-Secades, Alfonso J. López Rivero   +4 more
doaj   +1 more source

Design and Development of a Methodology Based on Expert Systems, Applied to the Treatment of Pressure Ulcers. [PDF]

Diagnostics (Basel), 2020
Casal-Guisande M, Comesaña-Campos A, Cerqueiro-Pequeño J, Bouza-Rodríguez JB.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prolog and expert systems [PDF]

, 1987
The first part of the thesis provides an introduction to the logic programming language Prolog and some areas of current research. The use of compilation to make Prolog faster and more efficient is studied and a modified representation for complex ...
Davies, Peter Leslie
core  

An evaluation of the performance of selected (Q)SARs/expert systems for predicting acute oral toxicity. [PDF]

Comput Toxicol, 2020
Nelms MD, Karmaus AL, Patlewicz G.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Expert Systems: Where Are We? And Where Do We Go from Here?

, 1982
Work on Expert Systems has received extensive attention recently, prompting growing interest in a range of environments. Much has been made of the basic concept and the rule-based system approach typically used to construct the programs.
Randall, Davis
core