Results 91 to 100 of about 60,361 (257)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
AutomatikaThis paper presents a novel approach for identifying system topology and detecting causal relationships between servers in Air Traffic Control systems (ATC) by utilizing unstructured, raw communication logs.
Agneza Krajna +3 more
doaj +1 more source
Experiments on ethnic or racial discrimination often use names to signal originin market situations under the assumption that non-ethnic name signals do notsystematically affect the outcome. Using survey data, we demonstrate significantvariation in perceived trustworthiness and professionalism of names within origins.Linking this to a large-scale name ...
Billie Martiniello +2 more
openaire +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Applied SciencesIn the context of autonomous driving, predicting pedestrian behavior is a critical component for enhancing road safety. Currently, the focus of such predictions extends beyond accuracy and reliability, placing increasing emphasis on the explainability ...
Angie Nataly Melo Castillo +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Frontiers in Digital HealthIntegrating multi-modal patient data to support personalized medicine has gained a lot of interest across different health domains over the past decade. Addressing this challenge requires the development and implementation of an informed, evidence-based ...
Emilia Daghir-Wojtkowiak +96 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Novel Actionable Counterfactual Explanations for Intrusion Detection Using Diffusion Models
Journal of Cybersecurity and PrivacyModern network intrusion detection systems (NIDSs) rely on complex deep learning models. However, the “black-box” nature of deep learning methods hinders transparency and trust in predictions, preventing the timely implementation of countermeasures ...
Vinura Galwaduge, Jagath Samarabandu
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source