Results 61 to 70 of about 127,128 (302)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Systematic Investigation of the Explicit, Dynamically Consistent Methods for Fisher’s Equation
ComputationWe systematically investigate the performance of numerical methods to solve Fisher’s equation, which contains a linear diffusion term and a nonlinear logistic term.
Husniddin Khayrullaev +2 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Implementation of multirate time integration methods for air pollution modelling [PDF]
Geoscientific Model Development, 2012 Explicit time integration methods are characterised by a small numerical effort per time step. In the application to multiscale problems in atmospheric modelling, this benefit is often more than compensated by stability problems and step size ...
M. Schlegel +3 more
doaj +1 more source
Mathematics, 2021 The finite element method has been widely used to investigate the mechanical behavior of biological tissues. When analyzing these particular materials subjected to dynamic requests, time integration algorithms should be considered to incorporate the ...
Jorge Grasa, Begoña Calvo
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Shock and Vibration, 2016 Time history analysis is becoming the routine process to quantify the response of the structure under dynamic loads. In this paper, a novel two-step unconditionally stable explicit integration algorithm, named Unconditional Stable Two-Step Explicit ...
Li Changqing +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Fast explicit time integration schemes for parabolic problems in mechanics [PDF]
We present a family of fast explicit time integration schemes of first, second and third order accuracy for parabolic problems in mechanics solved via standard numerical methods that have considerable higher computational efficiency versus existing ...
Oñate Ibáñez de Navarra, Eugenio +4 more
core +2 more sources