Results 71 to 80 of about 4,738,289 (324)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
SystemsIn highly dynamic and information-intensive logistics environments, understanding how firms achieve modeling and simulation ambidextrous innovation (MSAI) through strategic alignment is crucial.
Xinchen Wang, Mingjie Fang, Jia Shen
doaj +1 more source
Organizational Factors for Exploration and Exploitation
Journal of Technology Management & Innovation, 2009 The Purpose of the paper is to develop a conceptual framework which suggests a relationship between organisational factors and exploratory and exploitative innovation types.
Sharadindu Pandey, RRK Sharma
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Decision models in explorative and exploitative innovation projects: a case study [PDF]
, 2013 Innovation processes are seen as collections of decisions that are made in the context of a single innovation project. Those decisions determine the course and the final success of an innovation project.
Wolbers, Michiel +2 more
core +3 more sources
Journal of Open Innovation: Technology, Market and ComplexityAlthough the circular economy is increasingly recognized as a pathway to sustainable growth, how firms leverage digital platform capabilities and innovation to achieve circular economy outcomes remains underexplored, particularly in emerging economies ...
Huy Nhuong Bui +5 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
, 2021 Despite the acknowledged importance of innovation for enterprises’ sustainable development, in comparison to technological innovation, research on market-based innovation is still in its nascent stage. It is unclear what factors will predict market-
Chunpei Lin, Di Ye, Peixu He, Yana Pei
core +1 more source
Sustainability, 2019 Innovation activities of private firms are crucial for sustainable economic growth in every society. Therefore, the majority of firms around the world spend large amounts of capital (money, time, and human resources) in searching for novel innovative ...
Ming-Feng Tang +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source