Results 51 to 60 of about 56,888 (300)

Concept of comprehensive enterprises business model in global economic environment [PDF]

, 2020
The effective functioning of a modern enterprise necessitates the awareness of the owners and managers of its strategic orientations, the state of the internal and external environment, its competitive advantages, entrepreneurial potential and ...
Sardak, Sergii, Shvorak, Liydmila, Stakanov, Roman   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Exploring the dual effect of trust in GAI on employees’ exploitative and exploratory innovation

Humanities & Social Sciences Communications
The deployment of generative artificial intelligence (GAI) has attracted substantial research attention, yet its impact on employee innovation remains debated.
Xiaoyue Lin, Tiandong Wang, Fan Sheng
doaj   +1 more source

The Effects of Integrative Capability on Explorative Innovation and Exploitative Innovation [PDF]

, 2016
经济全球化背景下，环境变化加快，市场风险加剧。企业为巩固市场地位，开拓市场领域，选择与其他企业构建战略联盟。企业间通过获取应用外部资源和惯例，可以解决内部资源和惯例的竞争压力，协调企业同步进行探索性创新和应用性创新。应用性创新可以帮助企业从现有市场快速获取利润，探索性创新可以帮助企业从新的市场获取高额利润。然而联盟企业间的资源和惯例的匹配与协调并非自然发生，是需要合作企业有目的、有意识地培育与管理。很多联盟的失败归根到底是由于企业之间的整合不够充分。现有研究文献中 ...
林建东
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The impact of managerial autonomy and founding-team marketing capabilities on the relationship between ambidexterity and innovation performance

Journal of Open Innovation: Technology, Market and Complexity
Despite extensive research on the impact of ambidexterity strategy on firm performance, little is known about how team and individual factors affect innovation performance in new-venture businesses. In response to the call for research on the topic, this
Sabaa Sayed, Mumin Dayan
doaj   +1 more source

Organizational Factors for Exploration and Exploitation

Journal of Technology Management & Innovation, 2009
The Purpose of the paper is to develop a conceptual framework which suggests a relationship between organisational factors and exploratory and exploitative innovation types.
Sharadindu Pandey, RRK Sharma
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source