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How AI usage shapes employees’ exploitative and exploratory innovation: joy as a mediator and learning goal orientation as a moderator

Frontiers in Human Dynamics
IntroductionEmployees play a pivotal role in organizational ambidextrous innovation, yet existing studies have paid limited attention to how artificial intelligence shapes employees’ exploitative and exploratory innovation. Drawing on cognitive appraisal
Li Liu, Ya Lv
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The interplay of open innovation and strategic innovation: Unpacking the role of organizational learning ability and absorptive capacity

International Journal of Engineering Business Management, 2022
We explore the open innovation research model in order to remove barriers in service organizations, where lack of knowledge is the main barrier to innovation.
Saima Mirza, Asif Mahmood, Hassan Waqar
doaj   +1 more source

The Role of Knowledge-Oriented Leadership in Fostering Innovation Capabilities: The Mediating Role of Data Analytics Maturity

IEEE Access, 2023
The ability to continuously innovate has been widely realized as crucial for organizations to survive and be sustainable. One of the keys to successful innovation in a turbulent environment is leadership from top management and executives in ...
Destina Ratna Asih Khodijah Kadarsah, Rajesri Govindaraju, Budhi Prihartono   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Now or never: Organizational forgetting as a determinant of knowledge sharing and cross-boundary innovation

Frontiers in Psychology, 2022
This study constructs a theoretical model to test and prove that organizational forgetting influences cross-boundary innovation and testifies to the moderating role of Institutionalized organizational mission in the said relationship.
Xiaoyu Qu, Adnan Khan, Sajjad Ali
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Social Entrepreneurship That Truly Benefits the Poor: An Integrative Justice Approach [PDF]

, 2013
The phenomenal growth of social entrepreneurship over thelast decade has ably demonstrated how technology, innovation, and anentrepreneurial spirit can afford better solutions to the vexing social andenvironmental problems of our time than can ...
Santos, Nicholas J. C.
core   +3 more sources