Results 91 to 100 of about 135,077 (359)

Astrobiology and the Human Exploration of Mars [PDF]

open access: yes, 2010
In March 2007, the Mars Exploration Program Analysis Group (MEPAG) chartered the Human Exploration of Mars Science Analysis Group (HEM-SAG), co-chaired by J. B. Garvin and J. S. Levine and consisting of about 30 Mars scientists from the U.S.
Beaty, David   +3 more
core   +1 more source

Towards an integrated scientific and social case for human space exploration [PDF]

open access: yes, 2004
I will argue that an ambitious programme of human space exploration, involving a return to the Moon, and eventually human missions to Mars, will add greatly to human knowledge. Gathering such knowledge is the primary aim of science, but science's compart-
Crawford, Ian
core   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

EXPANDING NASA FUNCTIONALITY USING ITS API AND IMPROVING INTEREST AMONG PEOPLE IN SPACE EXPLORATION

open access: yesАвтоматизация технологических и бизнес-процессов
. This scientific work focuses on developing a website aimed at expanding the functionality of NASA’s API and increasing public interest in space exploration.
Y. V. Popov, K. O. Kirei
doaj   +1 more source

Office of exploration overview [PDF]

open access: yes
The NASA Office of Exploration case studies for FY89 are reviewed with regard to study ground rules and constraints. Three study scenarios are presented: lunar evolution, Mars evolution, and Mars expedition with emphasis on the key mission ...
Alred, John
core   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Rock size‐frequency distributions on Mars and implications for Mars Exploration Rover landing safety and operations [PDF]

open access: green, 2003
M. P. Golombek   +7 more
openalex   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

open access: yesMolecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides   +13 more
wiley   +1 more source

A Review of Environmental Challenges Facing Martian Colonisation and the Potential for Terrestrial Microbes to Transform a Toxic Extraterrestrial Environment

open access: yesChallenges
Mars is a focus of New Space Age exploration and colonisation, but there are significant challenges to successful colonisation by humankind.
Daniel Keaney, Brigid Lucey, Karen Finn
doaj   +1 more source

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