Results 91 to 100 of about 128,266 (357)
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
EXPANDING NASA FUNCTIONALITY USING ITS API AND IMPROVING INTEREST AMONG PEOPLE IN SPACE EXPLORATION
Автоматизация технологических и бизнес-процессов. This scientific work focuses on developing a website aimed at expanding the functionality of NASA’s API and increasing public interest in space exploration.
Y. V. Popov, K. O. Kirei
doaj +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
ChallengesMars is a focus of New Space Age exploration and colonisation, but there are significant challenges to successful colonisation by humankind.
Daniel Keaney, Brigid Lucey, Karen Finn
doaj +1 more source
Earth-Mars cyclers for a sustainable human exploration of Mars
Acta Astronautica, 2019 Abstract Since the early history of Space Exploration, Mars conquest has been the most important target. After Apollo mission's Moon landing, several concepts and projects, concerning a mission on the Red Planet, were developed. One of the most important contributes was given by Buzz Aldrin, who theorized the use of particular kind of orbits, called ...
Pelle, Stewart +6 more
openaire +3 more sources
Continuing the biological exploration of Mars [PDF]
Mars has been an object of interest for the better part of this century. To a biologist, Mars assumes special importance because many aspects of the theory of chemical evolution for the origin of life can be tested there.
Klein, Harold P.
core +1 more source
Getting Started in Mars Exploration [PDF]
This is an introduction in a series of activities on Mars that use images as integral parts of the lesson. Students are introduced to the images and begin a Mars journal. The purpose is to probe students' understanding of Mars to give the teacher a sense
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Advances in Astronomy, 2011 Viking missions reported adverse conditions for life in Mars surface. High hydrogen signal obtained by Mars orbiters has increased the interest in subsurface prospection as putative protected Mars environment with life potential. Permafrost has attracted
F. Gómez +9 more
doaj +1 more source