Results 101 to 110 of about 140,450 (312)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

International cooperation for Mars exploration and sample return [PDF]

The National Research Council's Space Studies Board has previously recommended that the next major phase of Mars exploration for the United States involve detailed in situ investigations of the surface of Mars and the return to earth for laboratory ...
Boynton, William V., Cameron, A. G. W., Carr, Michael H., Kitchell, Jennifer H., Levy, Eugene H., Mazur, Peter, Pace, Norman R., Prinn, Ronald G., Solomon, Sean C., Wasserburg, Gerald J.   +9 more
core   +1 more source

Research on the Detection Method of Martian Atmospheric Temperature and Pressure Profile Based on Laser Occultation Technology

Remote Sensing
As an important target of space exploration, Mars has attracted a lot of attention due to its unique geographical and atmospheric conditions. The detection of the vertical profiles of Mars atmospheric parameters provides deeper insights into the ...
Ye Liu, Wei Kong, Xue Shen, Tao Chen, Genghua Huang   +4 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Destination: Mars [PDF]

This set of lessons is designed to increase students' knowledge, awareness, and curiosity about the process of scientific exploration of Mars. Topics include navigating to Mars, investigating Martian soils and geology, mapping Martian landforms, and ...

core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An enhanced anti-disturbance guidance scheme for powered descent phase of Mars landing under actuator fault

International Journal of Advanced Robotic Systems, 2018
As a class of autonomous deep-space exploration robots, Mars lander is simultaneously affected by wind disturbance and actuator fault, which hinders precise landing on Mars.
Jianwei Xu, Jianzhong Qiao, Lei Guo
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Nuclear thermal propulsion workshop overview [PDF]

NASA is planning an Exploration Technology Program as part of the Space Exploration Initiative to return U.S. astronauts to the moon, conduct intensive robotic exploration of the moon and Mars, and to conduct a piloted mission to Mars by 2019.
Clark, John S.
core   +1 more source

Board 119: Innovative Mars Exploration Education and Technology Program: Development of an Informal Learning Curriculum (Work in Progress) [PDF]

, 2020
Srujal Patel, Maria-Isabel Carnasciali, Melissa L. Whitson, Daniel Schrage   +3 more
openalex   +1 more source