Results 81 to 90 of about 135,077 (359)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Planetary protection issues and human exploration of Mars [PDF]
A key feature of the Space Exploration Initiative involves human missions to Mars. The report describing the initiative cites the search for life on Mars, extant or extinct, as one of the five science themes for such an endeavor.
Devincenzi, D. L.
core +1 more source
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Life on ice, Antarctica and Mars [PDF]
The study of the origin of life and the prospects for human exploration of Mars are two themes developed in a new 57-minute film, Life on Ice, Antarctica, and Mars, produced by the InnerSpace Foundation and WHRO Television for broadcast by the Public ...
Anderson, D. T. +5 more
core +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Marsby and the Martian Detectives [PDF]
, 2004 This CD uses song and drama to tell the story of Spirit and Opportunity, NASA's Mars Exploration Rovers, and their mission to search for signs of ancient water. It includes an inquiry-based lesson.
core
Mars Science Helicopter Conceptual Design [PDF]
, 2020 Robotic planetary aerial vehicles increase the range of terrain that can be examined, compared to traditional landers and rovers, and have more near-surface capability than orbiters. Aerial mobility is a promising possibility for planetary exploration as
Balaram, Jayarao +15 more
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Earth-Mars cyclers for a sustainable human exploration of Mars
Acta Astronautica, 2019 Abstract Since the early history of Space Exploration, Mars conquest has been the most important target. After Apollo mission's Moon landing, several concepts and projects, concerning a mission on the Red Planet, were developed. One of the most important contributes was given by Buzz Aldrin, who theorized the use of particular kind of orbits, called ...
Pelle, Stewart +6 more
openaire +3 more sources