Results 51 to 60 of about 429,282 (303)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Geomorphological and hydrological controls on sediment export in earthquake-affected catchments in the Nepal Himalaya [PDF]

open access: yesEarth Surface Dynamics
Large earthquakes can contribute to mountain growth by building topography but also contribute to mass removal from mountain ranges through widespread mass wasting.
E. L. S. Graf   +5 more
doaj   +1 more source

Controlling the Transfer of Militarily Significant Technology: COCOM After Toshiba [PDF]

open access: yes, 1987
The Note argues that the Toshiba and Krongsberg sales illustrate the critical need of Western allies to agree on a functional means of promoting international trade without compromising international security.
Gregory, Joseph Edward
core   +1 more source

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress [PDF]

open access: yes, 2016
The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and ...
Cook, Gregory M   +7 more
core   +3 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

The Impact of US Export Controls on Korean Semiconductor Exports

open access: yesSSRN Electronic Journal
This study empirically investigates the impact of recent US export controls on China on South Korea’s semiconductor exports. We analyze South Korean export data to shed light on the repercussions of US export restrictions on a third country. Our findings reveal a significant decline in Korean semiconductor exports following the October 2022 imposition ...
Kim, Hanhin, Cho, Jaehan
openaire   +3 more sources

A Policy Overview, and Implications for the EU [PDF]

open access: yes, 2013
The post-Cold War international security environment has changed dramatically however, the proliferation of Weapons of Mass Destruction (WMD) continues to be one of the major global challenges and threats to security.
Zhao, Jizhou
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Myosin Va and Endoplasmic Reticulum Calcium Channel Complex Regulates Membrane Export during Axon Guidance

open access: yesCell Reports, 2016
During axon guidance, growth cones navigate toward attractive cues by inserting new membrane on the cue side. This process depends on Ca2+ release from endoplasmic reticulum (ER) Ca2+ channels, but the Ca2+ sensor and effector governing this asymmetric ...
Fumitaka Wada   +6 more
doaj   +1 more source

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