Results 71 to 80 of about 429,282 (303)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
The dubious success of export subsidies for wheat [PDF]
Farm produce ; Exports ; Export ...
Cletus C. Coughlin, Kenneth C. Carraro
core
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Politics and GovernanceThis article examines how export dependencies shape the EU’s industrial policy dynamics amid intensifying techno-nationalist rivalry between the US and China.
Jaša Veselinovič, Naná de Graaff
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann +17 more
wiley +1 more source
Journal of Forest ScienceHeadwater streams are key pathways for carbon (C) transfer from terrestrial to aquatic ecosystems. Sediments and plant litter constitute major C pools in streams, yet their roles in regulating dissolved carbon (DC) exports remain poorly understood. Here,
Zemin Zhao +7 more
doaj +1 more source
The economic impact of export controls : an application to Mongolian cashmere and Romanian wood products [PDF]
Countries sometimes use export controls on raw materials to encourage domestic processing. The motivation is usually to assure raw materials at low prices for domestic industries, although exports are sometimes controlled in an attempt to increase export
Takacs, Wendy E.
core
Private military services in the UK and Germany: Between partnership and regulation1 [PDF]
, 2005 Controversial cases such as the aborted coup in Equatorial Guinea and the employment of private contractors in the Abu Ghraib prison have brought the proliferation of private ‘mercenaries’ to worldwide attention.
Krahmann, E
core +1 more source