Results 61 to 70 of about 429,282 (303)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Hydrological controls on temporal contributions of three nested forested subcatchments to the export of dissolved organic carbon [PDF]

Hydrology and Earth System Sciences
Assessing the export of dissolved organic carbon (DOC) from terrestrial systems into inland waters reliably is of vital importance to understand the global carbon cycle in detail.
K. Blaurock, B. Beudert, L. Hopp
doaj   +1 more source

Analisis Implementasi Pengawasan Ekspor Impor Barang Pada Kppbc Tipe Madya Pabean Juanda [PDF]

, 2016
Indonesia one of the countries do export, import activities. In exporting / importing goods activity required controling. Institution that possesses of this is KPPBC Tipe Madya Pabean Juanda. The kind of research is descriptive qualitative approach.
Herlinawati, Y. (Yunita), Hidayat, K. (Kadarisman), Setyawan, A. (Arief)   +2 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

U.S.–China trade conflicts and R&D investment: evidence from the BIS entity lists

Humanities & Social Sciences Communications
The economic outcomes of U.S.–China trade conflicts on Chinese enterprises remain ambiguous. Using the staggered export control lists released by the Bureau of Industry and Security (BIS) of the U.S.
Han Hu, Shihui Yang, Lin Zeng, Xuesi Zhang   +3 more
doaj   +1 more source

Photoperiodic regulation of the sucrose transporter StSUT4 affects the expression of circadian-regulated genes and ethylene production

Frontiers in Plant Science, 2013
Several recent publications report different subcellular localisation of members of the SUT4 subfamily of sucrose transporters. The physiological function of SUT4 sucrose transporters is still not entirely clarified as down-regulation of members of the ...
Izabela eChincinska, Konstanze eGier, Undine eKrügel, Johannes eLiesche, Hongxia eHe, Bernhard eGrimm, Frans J.M. Harren, Simona eCristescu, Christina eKuehn   +8 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Strengthening Global Security: Critique on the NPT and NSG Mechanisms of Nuclear Export Control Regime

BTTN Journal
An export control regime plays a vital tool in the effort to counter the proliferation of traditional weapons and weapons of mass destruction. However, there are new and fundamental challenges with this system.
Nayyar Abbas Syed
doaj   +1 more source

RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

eLife, 2014
The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs. Multiple Rev subunits assemble on the Rev Response Element (RRE), a structured region present in these RNAs ...
Bhargavi Jayaraman, David C Crosby, Christina Homer, Isabel Ribeiro, David Mavor, Alan D Frankel   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source