Results 61 to 70 of about 17,830 (305)

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Model for Agricultural Production in Colombia Using a Neuro-Fuzzy Inference System

open access: yesComputers
As mentioned by the Food and Agriculture Organization of the United Nations, agriculture has a primary role in food security. Given the advantageous conditions that Colombia has as a biodiverse country, creating and implementing sustainable and ...
Andrea C. Gómez   +2 more
doaj   +1 more source

The Impact of Exports, Imports, and the Exchange Rate on Algeria’s Economic Growth [PDF]

open access: yesОблік і фінанси
This study examines the impact of foreign trade on economic growth in Algeria over the period 1980-2023. The main objective is to analyze the influence of exports, imports, and the exchange rate on economic growth to understand better the country’s trade
Amira Benachour   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

INTERNATIONALIZATION STRATEGIES: A CASE STUDY AT SMALL EXPORT COMPANIES

open access: yesFaces: Revista de Administração, 2009
The purpose of this study is to identify the main internationalization strategies used by small manufacturers of hammocks. Our findings show that these export companies have up to 20 employees and their main internationalization strategy is exportation ...
Elaine Di Diego Antunes   +1 more
doaj  

Cultural exportation is visible, leads to renewal and has an impact: Final report for the Cultural Export Promotion Programme 2007–2011

open access: yes, 2011
The Finnish Cultural Export Promotion Programme 2007–2011 was drawn up in cooperation by ministries and cultural players participating in the preparatory committee for cultural exportation during 2006 and 2007. The Committee’s report, Powering up Finnish

core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Port of Santarém: a logistical alternative for soybean grain export chains in Brazil

open access: yesCadernos Cajuína
Global demand for soybean grains in recent years has shown a strong upward growth trend and has been supplied primarily by Brazil, as the country has the largest expandable cultivation area and leads the export volume of this crop.
Fernanda Wanderley Rocha de Oliveira   +2 more
doaj   +1 more source

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