Results 61 to 70 of about 8,942 (264)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Port of Santarém: a logistical alternative for soybean grain export chains in Brazil
Cadernos CajuínaGlobal demand for soybean grains in recent years has shown a strong upward growth trend and has been supplied primarily by Brazil, as the country has the largest expandable cultivation area and leads the export volume of this crop.
Fernanda Wanderley Rocha de Oliveira +2 more
doaj +1 more source
Oilseeds and fats, crops and lipids, 2014 Cette recherche fournit une estimation de la production et des exportations d’huile d’olive tunisienne au marché européen en 2016. L’estimation des exportations a été réalisée pour deux scénarios de libéralisation totale et partielle ...
Karray Boubaker, Kanoun Fatma
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
Exportation Product Engeneering: the case of X Wood Company in the city of Ponta Grossa – PR
Revista Produção Online, 2007 This paper features a field research in a Wood Company located in the city of Ponta Grossa, State of Paraná, which from 2000 on started producing two items named “clear blocks” and “blanks”.
Arquimedes da Silva Szezerbicki +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Evaluation du paradigme économique d’une coopérative cacaoyère dans un contexte de la désindustrialisation de la RD Congo : exemple de la Cocama à Tshela [PDF]
Mouvements et Enjeux SociauxL’extension de la culture du cacao est bien manifeste dans plusieurs villages du Territoire de Tshela. L’intérêt de cette culture parait inversement proportionnel à la compétence des producteurs locaux.
Anselme KHONDE MBUNGU +1 more
doaj
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi +8 more
wiley +1 more source