Results 171 to 180 of about 22,508 (191)

SINE compounds activate exportin-1 degradation via an allosteric mechanism

The nuclear export receptor exportin 1 (XPO1/CRM1) is often overexpressed in cancer cells, leading to the mislocalization of numerous cancer-related protein cargoes1,2. Selinexor, a covalent XPO1 inhibitor, and other Selective Inhibitor of Nuclear Export (SINEs) restore proper nuclear localization by blocking XPO1-cargo binding2-7.
Casey Elizabeth Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Cagatay, Ashley B. Niesman, Maarten Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph M. Ready, Trinayan Kashyap, Sharon Shacham, Yosef Landesman, Rosa Lapalombella, Dirk Daelemans, Yuh Min Chook   +16 more
openaire   +1 more source

Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

Nature Chemical Biology
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication. Small molecules targeting XPO1 induce cytotoxicity, and selinexor was approved by the Food and Drug Administration in 2019 as a cancer chemotherapy for relapsed multiple
Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich, Brittany A. Cordova, Frederick N. Petroze, Ramya Srinivasan, Kevin C. Allan, David F. Yan, Joel L. Sax, Kelley Carr, Suzanne L. Tomchuck, Yuriy Fedorov, Alex Y. Huang, Amar B. Desai, Drew J. Adams   +14 more
openaire   +2 more sources

Selinexor. Exportin-1 (XPO1) inhibitor, Oncolytic

Drugs of the Future, 2014
null Riaz, W., null Burke, N., null Mahipal, A.   +2 more
openaire   +1 more source

INHIBITION OF EXPORTIN-1 DISRUPTS MYD88 DEPENDENT SIGNALING.

Shock, 2004
M. D. Walsh, K. A. Barsness, J. Y. Cha, J. H. Clarke, A. Banerjee, R. C. McIntyre   +5 more
openaire   +1 more source

Key role of exportin 6 in exosome-mediated viral transmission from insect vectors to plants

Proceedings of the National Academy of Sciences of the United States of America, 2022
Feng Cui
exaly  

Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1

Cell Reports, 2021
Cuige Zhu, Wang Faliang, Ziqian Li
exaly  

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5

Cancer Cell, 2016
Hui-Lung sun, Ri Cui, Jiankang Zhou
exaly  

A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells

Cancer Cell, 2010
Sonia A Melo, Catia Moutinho, Simona Rossi   +2 more
exaly  

EXPORTIN-1 MEDIATED NUCLEAR EXPORT OF MYD88 REGULATES LPS SIGNALING

Shock, 2003
K A Barsness, F Gamboni-Robertson, A Banerjee, R O McIntyre   +3 more
openaire   +1 more source

Exportin-5 orthologues are functionally divergent among species

Nucleic Acids Research, 2006
Takashi S Miki, Jun Katahira
exaly