Results 51 to 60 of about 38,621 (267)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Global value chain trade and sanction bypass: evidence from the United States

open access: yesFrontiers in Political Science
Global value chains and trade in intermediates have been proposed as one of the most important systemic changes in the global economic order. Besides their implication for the international trade, investment, and growth, we propose that they also have ...
Aydin B. Yildirim, J. Tyson Chatagnier
doaj   +1 more source

Problems of export orientation of Ukrainian industrial enterprises [PDF]

open access: yesMarketing i Menedžment Innovacij, 2016
The aim of the article.The purpose of the article is to study the current state of foreign trade in building materials and to identify the main barriers limiting exports in this area. The results of the analysis.
V.V. Smachylo, V.Yu. Khalina
doaj  

Indirect Exporters [PDF]

open access: yesJournal of Industry, Competition and Trade, 2012
Indirect exporters are defined as firms exporting through a trade intermediary. These firms have received rapidly expanding empirical and theoretical attention recently. I show that in Eastern Europe and Central Asia these firms do, as predicted by the theoretical literature, lie between domestic firms and direct exporters for a range of performance ...
openaire   +3 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

ROMANIAN FOOTWEAR INDUSTRY -EVOLUTIONS AND CHARACTERISTICS [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2014
Footwear industry represents an important sector in national economy. Most of its production goes to export, Romania being the 14th footwear exporter worldwide.
OFILEANU DIMI
doaj  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

IMPROVING THE FOREIGN POLICY OF RUSSIA ON THE BASIS OF THE GRAVITY MODELING (ON THE EXAMPLE OF THE BRICS)

open access: yesМодернизация, инновация, развитие, 2017
The article investigates the features of construction of gravity models, the results of the use of which will allow to identify eff ective ways of Russian foreign policy improvements.Purpose of the article: multigravitatsion development model of Russia's
E. A. Degtereva   +2 more
doaj   +1 more source

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