Results 101 to 110 of about 8,040,215 (350)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

MANAGING TRANSACTION EXPOSURE [PDF]

open access: yes
In the period of crisis the volatility of foreign exchange is one of most importantelements to be consider in the risk management strategy at corporate level .The paper will focus onthe main types of foreign exchange exposure, the role of hedging in ...
Dalina Dumitrescu
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Trade and Exposure [PDF]

open access: yes
Are firms that engage in trade more vulnerable to exchange rate risk? Or, put another way, that exchange rate movements will influence firm asset value through the trade channel.
Kathryn M.E. Dominguez, Linda L. Tesar
core  

Self-Optimizing Mechanisms for EMF Reduction in Heterogeneous Networks

open access: yes, 2014
This paper focuses on the exposure to Radio Frequency (RF) Electromagnetic Fields (EMF) and on optimization methods to reduce it. Within the FP7 LEXNET project, an Exposure Index (EI) has been defined that aggregates the essential components that impact ...
Altman, Zwi   +2 more
core   +1 more source

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]

open access: yes, 2020
Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing   +8 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Retrospective Surveillance of Wastewater To Examine Seasonal Dynamics of Enterovirus Infections

open access: yesmSphere, 2017
Enteroviruses are RNA viruses that are responsible for both mild gastroenteritis and mild respiratory illnesses as well as debilitating diseases such as meningitis and myocarditis.
Nichole E. Brinkman   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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