Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9‐tetrahydrocannabinol in BV‐2 microglial cells [PDF]
, 2011 Ana Juknat +7 more
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Lead exposure in an urban population of free-ranging kaka (Nestor meridionalis septentrionalis) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Science in Wildlife Health at Massey University, Palmerston North, Manawatu, New Zealand [PDF]
, 2017 Anthropogenic lead use has resulted in widespread environmental lead contamination known to affect wildlife populations worldwide. Lead is a highly toxic, non-essential heavy metal recognised as a cause of morbidity and mortality in birds ...
Sriram, Aditi
core
Out of the Lab and into the Bathroom: Evening Short-Term Exposure to Conventional Light Suppresses Melatonin and Increases Alertness Perception [PDF]
, 2013 Amely Wahnschaffe +7 more
openalex +1 more source
Fungicide Residues Exposure and β-amyloid Aggregation in a Mouse Model of Alzheimer’s Disease [PDF]
, 2020 Pierre‐André Lafon +12 more
openalex +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Retrospective Surveillance of Wastewater To Examine Seasonal Dynamics of Enterovirus Infections
mSphere, 2017 Enteroviruses are RNA viruses that are responsible for both mild gastroenteritis and mild respiratory illnesses as well as debilitating diseases such as meningitis and myocarditis.
Nichole E. Brinkman +2 more
doaj +1 more source
MANAGING TRANSACTION EXPOSURE [PDF]
In the period of crisis the volatility of foreign exchange is one of most importantelements to be consider in the risk management strategy at corporate level .The paper will focus onthe main types of foreign exchange exposure, the role of hedging in ...
Dalina Dumitrescu
core
Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]
, 2020 Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing +8 more
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