Results 71 to 80 of about 7,091,564 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Environmental Exposure, Biomonitoring and Exposure Assessment

Environmental exposure plays an important role in the development of diseases. However, individuals are exposed to complex mixtures of substances (e.g., chemicals, pollution, and diet) that change throughout a person’s life.

core   +1 more source

Efficient removal of ciprofloxacin using agro-waste biochar derived from soya stalks (Glycine max): Investigations on adsorption characteristics under varying environmental conditions

Water Resources and Industry
Mismanagement of antibiotics is a global problem affecting environmental and human health. In the present study, soya stalks (SS) derived biochars were prepared using thermochemical method for the effective removal of ciprofloxacin from water.
Bablu Alawa, Surya Singh, Sankar Chakma, Rupak Kishor, Cecilia Stålsby Lundborg, Vishal Diwan   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Human exposure to lead : report of the Human Exposure Assessment Location (HEAL) Programme Meeting, Bangkok, Thailand, 16-19 November 1992

, 1995
WHO/EHG/95.15216 ...
World Health Organization. Office of Global and Integrated Environmental Health, Human Exposure Assessment Location Programme. Meeting (1992 : Bangkok, Thailand)   +1 more
core  

Exposure and risk assessment of dioxins and PCBs in humans [PDF]

, 2010
The research described in this thesis was conducted to address health risks associated with occupational exposure to chlorophenoxy herbicides and dioxins (especially TCDD), with a special focus on specific health outcomes (cause specific mortality and ...
Dep IRAS, Boers, D., Risk Assessment of Toxic and Immunomodulatory Agents   +2 more
core   +1 more source

NIOSH Exposure Assessment Program [PDF]

"What are our priorities? The National Institute for Occupational Safety and Health (NIOSH) Exposure Assessment Program works with partners in industry, labor, trade associations, professional organizations, and academia. The program focuses on promoting

core   +1 more source

Results of 15 years of extended follow-up of the German porcelain workers cohort study: lung cancer and silicosis

Frontiers in Public Health
ObjectivesTo quantify, after extending follow-up 15 years, the relationship between occupational respirable crystalline silica (RCS) exposure and risk of silicosis diagnosis and lung cancer mortality in the German Porcelain Workers Cohort Study, and to ...
Thomas Birk, Kenneth A. Mundt, Lori Crawford, Patrizia Driesel   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source